Pengli Bu, Ph.D.

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Assistant Professor
Pharmaceutical Sciences
College of Pharmacy and Health Sciences
Ph.D., Toxicology, University of Kansas Medical CenterM.S., Biochemistry and Molecular Biology, Peking Union Medical College, ChinaB.S., Biochemistry and Molecular Biology, Shandong University, China

Dr. Pengli Bu joined St. John’s University in the Fall of 2022 as an Assistant Professor in the Department of Pharmaceutical Sciences in the College of Pharmacy and Health Sciences. Prior to Joining St. John’s University, Dr. Bu served as an Assistant Professor at Rosalind Franklin University of Medicine and Science (2019–22). Dr. Bu earned a Ph.D. in Toxicology from the Department of Pharmacology, Toxicology, and Therapeutics at the University of Kansas Medical Center and completed her postdoctoral training there in the Department of Pathology and Laboratory Medicine.

  • Reproductive pharmacology and toxicology
     
  • Harnessing herbal medicine for Leydig cell protection
     
  • Transporters in metabolic diseases
     
  • Safety assessment of biopharmaceuticals
  1. Ganieva U, Schneiderman S, Bu P, Beaman K, Svetlana Dambaeva. IL-22 regulates endometrial regeneration by enhancing tight junctions and orchestrating extracellular matrix. Frontiers in Immunology (2022) In Press  
     
  2. Zhang Y, Le Y, Bu P, Cheng X. Regulation of Hox and ParaHox genes by perfluorochemicals in mouse liver. Toxicology (2020) PMID: 32534105
     
  3. Desai H, Bu P, Shah A, Cheng X, and Serajuddin ATM. Evaluation of cytotoxicity of self-emulsifying formulations containing long-chain lipids using Caco-2 cell model: superior performance of long-chain lipids compared to medium-chain lipids. Journal of Pharmaceutical Sciences (2020) PMID: 32035926
     
  4. Bu P, Nagar S, Bhagwat M, Shah A, Zeng J, and Vancura A. DNA damage response activates respiration and thereby enlarges dNTP pools to promote cell survival in budding yeast. Journal of Biological Chemistry (2019) PMID: 31073026.
     
  5. Vancura A, Bu P, Bhagwat M, Zeng J, and Vancurova I. Metformin as an anticancer agent. Trends in Pharmacological Sciences (2018) PMID: 30150001.
     
  6. Vancura A, Nagar S, Kaur P, Bu P, Bhagwat M, Vancurova I. Reciprocal Regulation of AMPK/SNF1 and Protein Acetylation. International Journal of Molecular Sciences (2018) PMID:30366365.
     
  7. Le Y, Chen L, Zhang Y, Bu P, Dai G, and Cheng X. Epalrestat induced hepatic oxidative stress and liver fibrosis. Toxicological Sciences (2018) PMID: 28204799.
     
  8. Bu P, Yagi S, Shiota K, Alam S, Vivian J, Wolfe MW, Rumi M, Chakraborty D, Kubota K, Dhakal P and Soares MJ. Origin of a rapidly evolving homeostatic control system programming testis function. Journal of Endocrinology (2017) PMID: 28576872.

    Journal of Endocrinology is the official journal of the Society for Endocrinology.
     
  9. Zhang T, Bu P, Zeng J and Vancura A. Heme induces metabolic switch from fermentation to respiration through activation of Hap1p and the HAP complex. Journal of Biological Chemistry (2017) PMID: 28830930.
     
  10. Zou Y, Uddin MM, Padmanabhan S, Zhu Y, Bu P, Vancura A, and Vancurova I. The proto-oncogene Bcl3 induces immune checkpoint PD-L1 expression, mediating proliferation of ovarian cancer cells. Journal of Biological Chemistry (2017) PMID: 28167529.
     
  11. Bu P, Le Y, Zhang Y, Zhang Y, and Cheng X. Inactivation of Stat5 signaling by Berberine induced mouse and human sodium-taurocholate cotransporting polypeptide (Ntcp/NTCP) expression. Journal of Biological Chemistry (2017) PMID: 28154180.
     
  12. Vispute SG, Bu P, Le Y, Chen L, and Cheng X. Fibroblast growth factor (Fgf) 21 is a target gene of Glucocorticoid Receptor. Toxicology (2017) PMID: 28088388.
     
  13. Gatla HR, Zou Y, Uddin MM, Singha B, Bu P, Vancura A, and Vancurova I. Histone deacetylase (HDAC) inhibition induces IκB Kinase (IKK)-dependent interleukin-8/CXCL8 expression in ovarian cancer cells. Journal of Biological Chemistry (2017) PMID: 28167529.
     
  14. Bu P, LeY, Zhang Y, and Cheng X. Hormonal and chemical regulation of Glut9 transporter in mice. Journal of Pharmacology and Experimental Therapeutics (JPET) (2016) PMID: 27807007.

    Journal of Pharmacology and Experimental Therapeutics (JPET) is the official journal of the American Society for Pharmacology and Experimental Therapeutics (ASPET).
     
  15. Bu P, Ji Y, Narayanan S, Dalrymple D, Cheng X, and Serajuddin ATM.Assessment of cell viability and permeation enhancement in presence of lipid-based self-emulsifying drug delivery systems using Caco-2 cell model: Polysorbate 80 as the surfactant. European Journal of Pharmaceutical Sciences (2016) PMID: 28024890.

    European Journal of Pharmaceutical Sciences is the official journal of the European Federation for Pharmaceutical Sciences (EUFEPS).
     
  16. Bu P, Narayanan S, Dalrymple D, Cheng X, and Serajuddin ATM.Cytotoxicity assessment of lipid-based self-emulsifying drug delivery system in Caco-2 cell model: Cremophor EL as the surfactant. European Journal of Pharmaceutical Sciences (2016) PMID:27328127.
     
  17. Bu P, Alam SMK, Dhakal P, Vivian JL and Soares MJ. A prolactin family paralog regulates placental adaptations to a physiological stressor. Biology of Reproduction (2016) PMID: 26985002. Biology of Reproduction is the official journal of the Society for the Study of Reproduction.
     
  18. Xie M, Bu P, Li F, Lan S, Wu H, Yuan L, and Wang Y. Neonatal Bisphenol A exposure induces meiotic arrest and apoptosis of spermatogenic cells. Oncotarget (2016) PMID: 26863571.
     
  19. Soares MJ, Chakraborty D, Renaud SJ, Kubota K, Bu P, and Rumi MAK. Regulatory pathways controlling the endovascular invasive trophoblast cell lineage. Journal of Reproduction and Development (2012) PMID: 22790871.
     
  20. Konno T, Graham AR, Rempel LA, Ho-Chen JK, Alam SMK, Bu P, Rumi MAK, and Soares MJ. Subfertility linked to combined luteal insufficiency and uterine progesterone resistance. Endocrinology (2010) PMID: 20660062.
     
  21. Yang H, Bushue N, Bu P, and Wan YJ. Induction and intracellular localization of Nur77 dictate fenretinide-induced apoptosis of human liver cancer cells. Biochemical Pharmacology (2010) PMID:19912993.
     
  22. Dai G, He L, Bu P, and Wan YJ. Pregnane X receptor is essential for normal progression of liver regeneration. Hepatology (2008) PMID: 18167061.
     
  23. Bu P and Wan YJ. Fenretinide-induced apoptosis of Huh-7 hepatocellular carcinoma is retinoic acid receptor beta dependent. BMC Cancer (2007) PMID: 18166136.
     
  24. Bu P, Wang DM, Chen H, and Huang BR. Ectopic expression of epidermal growth factor-adenovirus e4orf4 fusion protein in tumor cells and characterization of its cytotoxicity. Cancer (2005) PMID: 15642197.
     
  25. Enoksson M, Robertson JD, Gogvadze V, Bu P, Kropotov A, Zhivotovsky B, and Orrenius S. Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids. Journal of Biological Chemistry (2004) PMID:15475367.
     
  26. Bu P and Chen H. Possible mechanisms of apoptosis induced by a protein factor adenovirus protein E4orf4. Microbiology Fascicule of Foreign Medical Science (2002).