group of pharmacy students in lab

Research

Serajuddin Research Lab

Pictured (from left to right): Nayan Solanki, Nitprapa Siriwannakij, Dr. Russell DiGate (Dean, College of Pharmacy & Health Sciences), Neha Chavan, Ankita Shah, Dr. Abu Serajuddin (Professor, Industrial Pharmacy), Anuprabha Meena, Dr. Mohammed Rashel (Post-doctoral Fellow), Amol Batra, Dr. Conrado "Bobby" Gempesaw (President, St. John’s University), Suhas Gumaste, Dr. Simerdeep Singh Gupta (Post-doctoral fellow), Yan Sun

Investigation of Novel Drug Delivery Systems and Processing Technologies in New State-of-the-Art Research Laboratories

The primary focuses of Prof. Serajuddin’s research are (1) the development of novel drug delivery systems, especially for poorly water-soluble drugs, and (2) the innovation in processing technologies for solid dosage forms. The current research projects in two modern state-of-the art research laboratories include:

  • Development of liquid and solid self-emulsifying drug delivery systems
  • Development of high-energy solids for enhancing dissolution rate of drugs
  • Supersolubilization and amorphization of drugs by acid-base interaction
  • Solid dispersion of poorly water-soluble drugs
  • Application of nanoparticle technology in oral bioavailability enhancement
  • Application of hot melt extrusion technology to dosage form development
  • Drug dissolution theory
  • In vitro-in vivo correlation
  • Melt granulation and wet granulation using twin-screw extruders
  • Application of twin-screw extruders to continuous manufacturing of solid dosage forms
  • Development of modified-release dosage forms using osmotic pump principles

For questions or general information about the laboratory, please email Dr. Serajuddin at [email protected].

 

Additional Information about the Serajuddin Research Lab

Nirali Patel

Educational Background

  • MS Industrial Pharmacy 2015- Present

  • M. Pharm (Clinical Pharmacy) KSV University, Gandhinagar, India 2014
  • B. Pharm KSV university, Gandhinagar, India 2012

Master's Thesis

  • Optimization of selection of polymer for solid dispersion based on polymer hygroscopicty and effect of water on polymer glass transition

Other Research Interests

  • Wet granulation
  • Effect of moisture on drug and excipient stability

Contact:
Email:  [email protected]
            [email protected]

Nitprapa Siriwannakij

Doctoral Student

Educational Background

  • PhD, St. John’s University, Sept 2014 to Current
  • MS, Rutgers University, Sept 2011 to Jan 2013       
  • B Pharm, Chulalongkorn University, Jun 2005 to Jun 2010 

Work Experience     

  • Quality Assurance Associate, Novel Laboratories May 2013 to Jun 2014
  • Research Associate, CU.D.H.I.P  Jun 2010 to Jul 2011

Other research interests

  • Solid-state characterization
  • Process Analytical Technology
  • Development of poorly soluble drug

Contact 

Email: [email protected]  

Nayan Solanki

Doctoral Student

Education

  • Ph.D., St. John’s University, 2014-present
  • M. Pharm, Ahmedabad University, 2013
  • B. Pharm, Saurashtra University, 2011

Ph.D Thesis

  • Area of work: Melt extrusion, 3-D Printing

M. Pharm Thesis:

  • Design and Development of Ketorolac Modified Release Pellets

Publication:

  • Gupta SS, Solanki N, Serajuddin AT. Investigation of Thermal and Viscoelastic Properties of Polymers Relevant to Hot Melt Extrusion, IV: Affinisol™ HPMC HME Polymers. AAPS PharmSciTech, February 2016.

Podium Presentation:

  • Application of Oscillatory Rheology to Evaluate Soluplus®-Itraconazole Miscibility Relevant to Hot-melt Extrusion, AAPS-North East Regional Discussion Group, Hartford, CT- April 2016

Poster Presentations:

  • Application of Oscillatory Rheology to Evaluate Miscibility and Identify Processing Conditions for Melt Extrusion of Soluplus®-Itraconazole Mixtures, New Jersey Pharmaceutical Association for Science and Technology (NJPhAST) meeting, East Hanover, NJ – May 2016
  • Effect of Added Polymers on Viscoelastic Properties of Hydroxypropyl Methylcellulose Acetate Succinate (HPMC-AS) Relevant to Melt Extrusion, AAPS meeting, Orlando, FL – October 2015
  • Investigation of Thermal and Viscoelastic Properties of Polymers Relevant to Hot Melt Extrusion, IV: Affinisol™ HPMC HME Polymers, AAPS meeting, Orlando, FL – October 2015 

Award:

  • Manufacturing Science and Engineering (MSE) travelship award, AAPS annual meeting, Orlando, 2015.

Other Interests:

  • Twin screw granulation
  • Rheology

Contact

Email: [email protected]
Linkedin: Nayan Solanki

Md Tahsin

Masters Student

Education:

  • Master’s in Industrial Pharmacy, Since 2015
  • Bachelor in Pharmacy from State University of Bangladesh, Dhaka, Bangladesh, 2014

B. Pharm Thesis:

  • Preparation and Evaluation of Acetaminophen Oral Thin Films

Master's Thesis:

  • Working on Hot Melt Extrusion and 3D Printed Dosage Forms

Internship:

  • Incepta Pharmaceuticals Ltd, Dhaka, Bangladesh, January 2014 to March 2014

Contact:

Jaydip Vasoya

Doctoral Student                                                                    

Educational Background

  • Ph.D. student since  2015
  • M. Pharm., B.K. Mody Govt. Pharmacy College, India, 2014
  • B. Pharm, B.K. Mody Govt. Pharmacy College, India, 2012

Master’s Thesis

  • Development and characterization of multifunctional directly compressible co-processed orodispersible excipient.

Publication

  • J M Vasoya, S V Nathwani, and R S Nathwani, A Co-processed pharmaceutical excipient WO2016046693 A1, PCT/IB2015/057095.

Research Interests

  • Hot melt extrusion for amorphous solid dispersions
  • Co-crystal and salt synthesis with hot melt extrusion
  • Polymer-lipid based formulation systems
  • 3D printing for amorphous formulations

Contact

Email: [email protected]"
LinkedIn: Jaydip Vasoya

Amol Batra ​​

Doctoral Student

Educational Background

  • Ph.D., St. John’s University, 2016
  • Bachelor of Pharmacy, College of Pharmacy, University of Delhi, India, 2007

PhD Thesis

  • Area of work: Melt Granulation

Internships

  • Talwar Research Institute, Delhi, India, Feb 2008 to June 2008. Expression and purification of hCGβ-LTB expressed in recombinant yeast Pichia Pastoris,
  • Novartis Pharmaceuticals, East Hanover,NJ. May 2009 to August 2009. Use of design of experiments for testing robustness of dissolution process for a Novartis product.

Other research interests

  • Melt extrusion
  • Cocrystals
  • Crystallization processes and kinetics
  • Application of quality by design to pharmaceutics

Contact
[email protected]

Anuprabha Meena

Doctoral Student

Educational Background

  • Ph.D., St. John’s University, NY, USA, 2016
  • M.S., Birla Institute of Technology, Mesra, India 2007
  • B Pharm, Birla Institute of Technology, Mesra, India, 2005

Ph.D. Thesis

  • Continuous wet granulation using twin screw extruder

M.S. Thesis

  • Formulation and evaluation of chrono release tablet of metoprolol succinate
  • Work ExperienceJunior Manager, Dr. Reddy’s Lab. Hyderabad, India, June 2007 – July 2008.
  • Formulation of pulsatile release pellet system of antidiabetic drug, Microsphere based gels and creams for dermatological application

Publications

  • Meena, A., Parikh, T., Gupta, S. S., & Serajuddin, A. T.M. Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion, II: Cellulosic polymers, Journal of Excipients and Food Chemicals, March 14, 2014, 5 (1), 46 – 55
  • Parikh, T., Gupta, S. S., Meena, A., & Serajuddin, A. T.M. Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion, III: polymethacrylates and polymethacrylic acid based polymers, Journal of Excipients and Food Chemicals, 2014, 5 (1), 56 - 64
  • Gupta, S. S., Meena, A., Parikh, T., & Serajuddin, A. T.M. Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion, I: Polyvinylpyrrolidone and related polymers, Journal of Excipients and Food Chemicals, 5 (1), 32 – 45, March 11, 2014

Posters

  • Thermal and viscoelastic properties of polymers relevant to hot melt extrusion
  • Effect of presence of drugs on viscoelastic properties and extrudability of Soluplus, a graft copolymer
  • Application of film casting technique to predict drug polymer miscibility and physical stability of hot melt extrudates
  • Presented at ExcipientFest, NJPhAST, Jarowski Symposium &NERDG in 2013

Awards

  • Winner (1st Place) of Academic poster in Excipient Fest, 2013

Other research interests

  • Film casting and hot melt extrusion
  • Thermal and rheological evaluation of binary systems
  • Solubility and dissolution enhancement of poorly water soluble drugs

Additional Activities
AAPS Student Chapter Vice Chair (2010-2011)

Contact
[email protected]

Suhas Gumaste

Doctoral Student

Educational Background

  • Ph.D., St. John’s University, 2016
  • M.S., St. John’s University, 2012
  • B. Pharm, University of Pune, 2008

Ph.D Thesis: 

  • Solidification of Self-Emulsifying Lipid Based Formulations by Adsorption on Silicas: Effect of Preconcentrate Composition and Silica Microstructure

M.S. Thesis

  • Development of Lipid Based Self Emulsifying Tablets by Adsorption of Microemulsion Preconcentrates on Neusilin® US2

Work Experience            

  • Production Pharmacist (Granulation), Emcure Pharmaceuticals Limited, Jun 2008-Jul 2009

Internship

  • Formulation Sciences Co-op,      Merck,  Jun 2012-Nov 2012

Publications

  • Gumaste SG, Gupta SS, Serajuddin AT. Investigation of Polymer-Surfactant and Polymer-Drug-Surfactant Miscibility for Solid Dispersion. The AAPS Journal. 2016 Jun 14:1-3. doi:10.​1208/​s12248-016-9939-5
  • Gumaste SG, Pawlak SA, Dalrymple DM, Nider CJ, Trombetta LD, Serajuddin ATM. Development of Solid SEDDS, IV: Effect of Adsorbed Lipid and Surfactant on Tableting Properties and Surface Structures of Different Silicates. Pharm Res 2013 Jun 26; DOI 10.1007/s11095-013-1114-4
  • Gumaste SG, Dalrymple DM, Serajuddin ATM. Development of Solid SEDDS, V: Compaction and Drug Release Properties of Tablets Prepared by Adsorbing Lipid-Based Formulations onto Neusilin® US2. Pharm Res. 2013 Jun 25 DOI 10.1007/s11095-013-1106-4

Podium Presentation

  • Development of Lipid Based Self Emulsifying Tablets by Adsorption of Microemulsion Preconcentrates on Neusilin® US2, AAPS Northeast Regional Discussion Group 2012, Rocky Hill, C.T., 2012

Poster Presentations

  • Development of Lipid Based Self Emulsifying Tablets by Adsorption of Microemulsion Preconcentrates on Neusilin® US2, AAPS Northeast Regional Discussion Group 2012, Rocky Hill, C.T., 2012 & AAPS Annual Meeting, Washington D.C., 2011
  • Construction of a Ternary Phase Diagram of a Poorly Water Soluble Drug in Presence of Hydrophilic Polymer and a Surfactant: Itraconazole, Soluplus® and Kolliphor® P 188, St. John’s University, Charles I. Jarowski Symposium, 2013

Awards

  • ‘AAPS FDD Section Travelship Award’, AAPS Annual Meeting and Exposition, Chicago, Oct 14-18, 2012.
  • NJPhAST Graduate Scholarship Award 2012
  • Charles I Jarowski Legacy Endowed Scholarship Award 2014
  • Catalent R&D recognition award

Other Research Interests

  • Solid dosage form development
  • Compaction mechanics
  • Lipid based delivery systems
  • Ionic Liquids

Contact
[email protected]
LinkedIn: Suhas Gumaste

Simerdeep Singh Gupta

 

PhD graduation:  May 2014

Post Doctoral Research Fellow2016

Educational Background

  • Ph.D. in Industrial Pharmacy, St. John’s University, New York 11439. (August 2010-2014)
  • Master’s in Industrial Pharmacy, St. John’s University, New York 11439. (Fall 2007- Spring 2010)
  •  Bachelor in Pharmacy, Bharati Vidyapeeth College of Pharmacy, Mumbai University. (2002-2006)

Research Interests and Projects

  • Solubilization
  • Hot Melt Extrusion
  • Co-crystals
  • Supercritical Fluid Technology
  • Nanotechnology for Drug Delivery
  • Brain Targeting of Hydrophilic Drugs
  • “Development of a novel process to prepare pegylated polymeric nanoparticles loaded with a hydrophilic drug by nanoprecipitation of sprayed polymeric solution.” (Master’s research)

Honors and Awards

  • Won Modified Release Focus Group-Schering Plough travelship award at AAPS conference LA,2009

Presentations:
Poster

  • Presented at CRS conference at Honolulu, HI on “Effect of Drug Concentration and Processing Temperature on Extrudability and Miscibility of Solid Dispersions by Hot Melt Extrusion” – July 2013
  • Presented at NJPhAST at NJ on “Effect of Drug Concentration and Processing Temperature on Extrudability and Miscibility of Solid Dispersions by Hot Melt Extrusion” – May 2013
  • Presented at NERDG conference at Rocky Hill, CT on “Effect of Presence of Drugs on Viscoelastic Properties and Extrudability of Soluplus®, a Graft Copolymer” – April 2013

Podium

  • Presented at the 'Polymers in Medicine' workshop at Case Western Reserve University, Cleveland, OH on "Viscosity and Extrudability of Selected Polymers in Presence of Drug" - January 2013

Publications:

  • Bommana, M. M., Kirthivasan, B., Shikhar, A., Gupta, S. S., & Squillante, E. (2013). In vivo brain microdialysis as a formulation-screening tool for a poorly soluble centrally acting drug. Drug Development and Industrial Pharmacy, Early Online
  • Gupta, S. S., Parikh, T., Meena, A. K., Mahajan, N., Vitez, I., & Serajuddin, A. T. (2014). Effect of Carbamazepine on Viscoelastic Properties and Hot Melt Extrudability of Soluplus®. International Journal of Pharmaceutics, Volume 478, Issue 1, 15 January 2015, Pages 232–239 The other JEFC publications are published.
  • Parikh, T., Gupta, S. S., Meena, A., & Serajuddin, A. T.M. Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion, III: polymethacrylates and polymethacrylic acid based polymers, Journal of Excipients and Food Chemicals, 2014, 5 (1), 56 - 64
  • Meena, A., Parikh, T., Gupta, S. S., & Serajuddin, A. T.M. Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion, II: Cellulosic polymers, Journal of Excipients and Food Chemicals, March 14, 2014, 5 (1), 46 - 55
  • Gupta, S. S., Meena, A., Parikh, T., & Serajuddin, A. T.M. Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion, I: Polyvinylpyrrolidone and related polymers, Journal of Excipients and Food Chemicals, 5 (1), 32 – 45, March 11, 2014
  • Murali Mohan Bommana, Abhijat Shikhar, Bharat Kirthivasan, Simerdeep Singh Gupta, Tapan Parikh and Emilio Squillante. Influence of Supercritical Carbon Dioxide For Pharmaceutical Processing: From Infancy to Present. Advances in Material Science Research, New York: Nova science publishers, 18, 161- 176.

Awards:

  • Won the NJPhAST scholarship for a poster presentation at NJPhAST meeting in New Jersey – May 2013
  • FDD travelship award
  • Catalent R&D recognition award

Additional activities

  • Chair, AAPS Student chapter: (2012-13 term): Leading and managing AAPS student chapter at St. John's University. Conducting seminars, presentations, equipment demonstrations, industrial visits and trips to various conferences.

Contact Information
[email protected]
[email protected]
LinkedIn: Simerdeep Singh Gupta

Darshil Patel

Educational Background

  • Regulatory Affairs Certification- US, RAPS, May 2012
  • M.S., St. John’s University, 2010
  • B. Pharm, A.R. College of Pharmacy, 2007

M.S. Thesis

  • Comparative Evaluation of Propylene Glycol Monoester, Propylene Glycol Diester and Triglyceride of Medium Chain Fatty Acids by Lipid-Surfactant-Water Phase Diagrams, Drug Solubility, and In-Vitro Dispersion Tests.

Work Experience            

  • Research Associate, Medical Products Laboratories, Oct 2010 to Present

Publications

  • Enhanced microemulsion formation in lipid-based drug delivery systems by combining mono-esters of medium chain fatty acids with di- or tri-esters. Patel D., Li P., Serajuddin ATM.  Journal of Excipients and Food Chemicals. 2012; 3(2):29-44.
  • Effect of Difference in Fatty Acid Chain Lengths of Medium-Chain Lipids on Lipid-Surfactant-Water Phase Diagrams and Drug Solubility. Journal of Excipients and Food Chemicals. Patel D., Prajapati H., Patel N., Dalrymple D., Serajuddin ATM. 2011; 2(3):73-88.

Posters

  • Comparative Study of Propylene Glycol Monoester, Propylene Glycol Diester and Triglyceride Forms of Medium Chain Fatty Acids for Their Effects on Nanoemulsion Formation and Drug (danazol) Solubility.  2010 AAPS Annual Meeting And Exposition, New Orleans, LA, November 2010
  • To investigate effect of the fatty acid chain length on Nanoemulsion Formation and Drug Solubility. 2010 AAPS Annual Meeting And Exposition, New Orleans, LA, November 2010

Awards

  • Best Manuscript Award 2013, IPEC Foundation, Journal of Food Excipents and Chemicals

Contact
[email protected]
Linkedin: Darshil Patel

Nrupa Patel

Educational Background

  • M.S., St. John’s University, NY, Aug 2009 to Jan 2012
  • B. Pharm, Rajiv Gandhi University of Health Sciences, Bengaluru, India (RGUHS), 2004 to  2008

M.S. Thesis

  • Development of Solid SEDDS using Lauroyl- and Stearoyl-polyoxylglycerides as Solidifying Agents for Liquid Self-Emulsifying Formulations of Triglycerides.

Work Experience             

  • Research Scientist, Navinta LLC, Feb 2012 to present, Sterile formulation development

Publications

  • Effect of Difference in Fatty Acid chain lengths of medium-chain lipids on Lipid/Surfactant/Water phase diagrams and drug solubility. Prajapati H., Patel D., Patel N., Dalrymple D., Serajuddin A.; Journal of Excipients and Food Chemicals, North   America, Aug 2011.
  • Development of Solid SEDDS, II: Application of Acconon® C-44 and Gelucire® 44/14 as solidifying agents for self-emulsifying drug delivery systems of medium chain triglycerides. Patel N., Prajapati H., Dalrymple D., Serajuddin A.; Journal of Excipients and Food Chemicals, North   America, June 2012.
  • Development of Solid SEDDS, III: Application of Acconon® C-50 and Gelucire® 50/13 as both solidifying and emulsifying agents for medium chain triglycerides. Patel N., Dalrymple D., Serajuddin A.; Journal of Excipients and Food Chemicals, North   America, June 2012.

Posters

  • Effect of Difference in Fatty Acid Chain Length of Medium-Chain Lipids on Drug Solubility and Lipid-Surfactant-Water Phase Diagrams.
  • Formulation and Characterization of Solid Microemulsion Preconcentrate System for Medium Chain Triglyceride Using Lauroyl Macrogolglycerides as Solidifying agents

Presented at AAPS-NERDG (Northeast Regional Discussion Group) Annual Meeting, AAPS Annual Meeting, AAPS NERDG Summer Meeting, NJPhAST, Jarowski Symposium, CT/DC/NJ/NY 2011, 2012
Awards

  • Outstanding Poster Award at New Jersey Pharmaceutical Association for Science and Technology (NJPhAST) Annual Student Scholarship Award Meeting, May 19th 2011

Other Research Interests             

  • Sterile formulation development, lyophilization technology
  • Enhancing solubility of poorly soluble drugs
  • Lipid based drug delivery
  • Solid nano self emulsifying drug delivery system

Contact
[email protected]
LinkedIn: Nrupa Patel

Saad Muntazim

Educational Background

  • M.S., St. John’s University, NY, April 2013
  • B. Pharm, University of Asia Pacific, September 2008

M.S. Thesis

  • Dissolution Enhancement of Ziprasidone HCl using Hot Melt Extrusion

Posters Presentation

  • Dissolution Enhancement of Ziprasidone HCl by Melt Extrusion, AAPS Annual Meeting and Exposition, Chicago, IL, Oct 2012

Contact
[email protected]


Tapan Parikh

 

Doctoral Candidate
PhD graduation:  Sept 2014

Current Title and Affiliation:
Staff Fellow (CMC Reviewer), Division of Modified Release Dosage Form,, Center of Drug Evaluation and
Research, Food and Drug Administration, Silver Spring, MD 20903, USA

Educational Background

  • Ph.D. in Industrial Pharmacy, PhD, St. John’s University, Spring 2010 to present
  • M.S. in Industrial Pharmacy, MS, St. John’s University, 2007
  • Bachelor’s in Pharmacy, B Pharm, V.I.P.S., Rajiv Gandhi University, Bangalore, India 2004

PhD Thesis

  • Development and stabilization of high energy solids for poorly soluble drugs

M.S. Thesis

  • Efficacy of surface charge in targeting pegylated nanoparticles of sulpiride to brain

Work Experience

  • Research Associate, Nostrum Pharmaceuticals, Feb 2008 to Dec 2009.
  • Development and scale up of generic formulations for delayed and extended release products
  • Preparation of technical documents for electronic submission to FDA

Publications
Published Articles

  • Murali Mohan Bommana, Abhijat Shikhar, Bharat Kirthivasan, Simerdeep Singh Gupta, Tapan Parikh and Emilio Squillante. Influence of Supercritical Carbon Dioxide For Pharmaceutical
  • ​Processing: From Infancy to Present. Advances in Material Science Research, New York: Nova science publishers, 18, 161- 176
  • Gupta, S. S., Parikh, T., Meena, A. K., Mahajan, N., Vitez, I., & Serajuddin, A. T.M. Effect of Carbamazepine on Viscoelastic Properties and Hot Melt Extrudability of Soluplus® International Journal of Pharmaceutics, 2014; 478 (1): 232-239
  • Parikh, T., Gupta, S. S., Meena, A., & Serajuddin, A. T.M. Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion, III: polymethacrylates and polymethacrylic acid based polymers, Journal of Excipients and Food Chemicals, 2014, 5 (1), 56 - 64
  • Meena, A., Parikh, T., Gupta, S. S., & Serajuddin, A. T.M. Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion, II: Cellulosic polymers, Journal of Excipients and Food Chemicals, March 14, 2014, 5 (1), 46 - 55
  • Gupta, S. S., Meena, A., Parikh, T., & Serajuddin, A. T.M. Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion, I: Polyvinylpyrrolidone and related polymers, Journal of Excipients and Food Chemicals, 5 (1), 32 – 45, March 11, 2014

 

Accepted Publications

  • Singh, S., Parikh, T., Sandhu, H., Shah, N., Malick, W., Singhal, D., Serajuddin, ATM. Supersolubilization and amorphization of a model basic drug, Haloperidol, by interaction with weak acid. Pharm. Res. 2013 Jun, 30, 6, 1561- 73.
  • Parikh, T., Bommana, M., Squillante III, E. Efficacy of surface charge in targeting pegylated nanoparticles of sulpiride to the brain. EJPB. 2010 Mar, 74, 3, 442-450.

Expected to be submitted

  • Investigation of thermal and visoelastic properties of polymers relevant to hot-melt extrusion, 1: Polyvinyl based polymers.
  • Investigation of thermal and visoelastic properties of polymers relevant to hot-melt extrusion, 2: Cellulose and related copolymers.
  • Investigation of thermal and visoelastic properties of polymers relevant to hot-melt extrusion, 3: Polymethacrylates and methacrylic acid based copolymers.

Podium Presentations

  • Invited speaker on “Role of Physico-Chemical properties of polymers in Hot melt Extrusion”, 2nd Enhancing Drug Bioavailability and solubility enhancement conference, Boston, MA., Jan 2013
  • “Application of film casting technique to predict drug polymer miscibility and physical stability of hot melt extrudates.”, NERDG-ARA Conference, Rocky Hill, CT, April 2013

Poster Presentations

  • Development of amorphous solid dispersion of itraconazole using weak organic acids”, AAPS Annual conference, San Antonio, TX, Nov 2013
  • Targeted brain drug delivery of sulpiride using cationized albumin based nanoparticles “AAPS Annual conference” San Diego, CA. Nov 2007

Awards
AAPS travelship award at AAPS Annual conference 2013 from FDD Section

Other research interests

  • Melt extrusion
  • Spray drying
  • Nanotechnology
  • Intellectual properties

Additional Activities

  • Chair: “AAPS St. John’s University student chapter, 2011- 2012”

Contact
[email protected]
[email protected]
LinkedIn: Tapan Parikh


Hetal Prajapati

 

Doctoral Student

Educational Background

  • Ph.D., St.John’s University, graduation: Sept 2014
  • M.S., St.John’s University, 2010
  • B. Pharm, L.M.College of Pharmacy, 2007
  • Ph.D. Thesis
    Sugar ester derivatives as nanoparticles stabilizer and dispersant

Current Title and Affiliation:  Scientist, Formulation R&D, Abon Pharmaceuticals, NJ, Sept 2014-Present

M.S. Thesis

  • Comparative Evaluation of Monoglyceride, Diglyceride and Triglyceride of Medium Chain Fatty Acids by Lipid-Surfactant-Water Phase Diagrams for Application in Pharmaceutical Dosage Form Development

Work Experience

  • Research Associate Intern, Emcure Pharmaceuticals, Dec 2010 –Jan 2011, Formulation and development of oral solid dosage forms and lipid based delivery systems

Publications

  • Prajapati H, Dalrymple D, Serajuddin ATM. In Vitro Dispersion Test Can Serve as a Predictive Method for Assessing Performance of Lipid-based Drug Delivery Systems. Submitted to International Journal of Pharmaceutics.
  • Prajapati H, Dalrymple D, Serajuddin ATM. A Comparative Evaluation of Mono-, Di- and Triglyceride of Medium Chain Fatty Acids by Lipid/Surfactant/Water Phase Diagram, Solubility Determination and Dispersion Testing for Application in Pharmaceutical Dosage Form Development. Pharm Res. (2012) 29:285–305
  • Patel N, Prajapati H, Dalrymple D, Serajuddin ATM. Development of Solid SEDDS, II: Application of Acconon C-44® and Gelucire 44/14® as Solidifying Agents for Self-emulsifying Drug Delivery Systems of Medium Chain Triglyceride. Journal of Excipients and Food Chemicals. 2012; 3(2):54-66
  • Prajapati H, Patel D, Patel N, Dalrymple D, Serajuddin ATM. Effect of Difference in Fatty Acid Chain Lengths of Medium-Chain Lipids on Lipid-Surfactant-Water Phase Diagrams and Drug Solubility. Journal of Excipients and Food Chemicals. 2011; 2(3):73-88.

Podium Presentation

  • Development of Solid SEDDS using Lauroyl- and Stearoyl - polyoxylglycerides as Solidifying Agents for Liquid Self-Emulsifying Formulations of Triglycerides, 2012 AAPS—NERDG Annual Conference, Rocky Hill, CT, Apr 2012

Poster Presentations

  • A Comparative Evaluation of Mono-, Di- and Triglyceride of Medium Chain Fatty Acids by Lipid/Surfactant/Water Phase Diagram, Solubility Determination and Dispersion Testing for Application in Pharmaceutical Dosage Form Development, 2011 AAPS—NERDG Annual Conference, Rocky Hill, CT, Apr 2011
  • Characterization of Medium Chain Fatty Acids for   Nanoemulsion Formation and Drug Solubility. I. Comparative Study of Mono-, Di- and Tri-Glycerides . 2010 NJPhAST Scholarship Poster Presentation New Jersey May 2010
  • Systematic Study of Effects of Mono-, Di- and Tri Glycerides of Medium Chain Fatty Acids on Development of Lip id-based Drug Delivery Systems. 2010 FIP PSWC and AAPS Annual Meeting New Orleans, LA, Nov 2010
  • Effect of Fatty Acid Chain Length in Propylene Glycol Mono- and Di-ester Lipids on Micro- and Nano-emulsion Formation and Drug Solubility, 2010 FIP PSWC and AAPS Annual Meeting New Orleans, LA, Nov 2010

Awards

  • NERDG-AAPS Academic Research Award 2011
  • NJPhAST Graduate Scholarship 2010
  • AAiPS Research Scholarship Award 2010

Other research interests

  • Nanotechnology
  • Solid dispersion technology
  • Oral solid dosage forms
  • Lipid based drug delivery system
  • Solid state characterization

Contact
[email protected]
[email protected]
LinkedInHetal Prajapati

Saumya Singh

Educational Background

  • M.S., St. John's University, NY, 2011
  • M. Pharm., Birla Institute of Technology and Science, Pilani (BITS, Pilani), India, 2009
  • PG Diploma, Clinical trials and administration, 2008
  • B. Pharm., Seth G.L.Bihani College of Technical Education, India, 2007

M. Pharm Thesis

  • Design and evaluation of gastroretentive oral controlled release formulation of an anti- viral drug

M.S. Thesis 

  • Supersolubilization and amorphization of a model basic drug, haloperidol by interaction with weak acids

Internship Thesis

  • Design and evaluation of a novel formulation of an anti-fungal drug based on layer- by- layer technology and to evaluate efficacy of the formulation using entrapment efficiency study

Work Experience             

  • Scientist, SSCI, A division of Aptuit, West Lafayette, IN, Aug 2012-Current
  • Formulation Scientist, Advanced testing laboratory, on site Proctor & Gamble Co. Cincinnati, OH, Feb 2012- July 2012

Internship

  • Research intern, Central Drug Research Institute (CDRI), Lucknow, India, Jan 2009- June 2009
  • Summer intern, Idma Laboratories Ltd. Haryana, India, May 2006- July 2006

Publications

  • Singh S, Parikh T,  Sandhu HK, Shah NH,  Malick AW, Singhal D, Serajuddin ATM, Supersolubilization and Amorphization of a Model Basic Drug Haloperidol by Interaction with Weak Acids, Pharm Res, 2013 Pharmaceutical Research, Vol. 30, issue 6 (June 2013), p. 1561 – 1573.

Poster Presentation

  • Supersolubilization and Amorphization of a Model Basic Drug Haloperidol by Interaction with Weak Acids, American Association of Pharmaceutical Sciences (AAPS) Chicago, IL Oct- 2012

Contact
[email protected]
[email protected]
LinkedIn: Saumya Singh

Mohammad Rashel

Research Associate

Educational Background

  • PhD, Kochi Medical School, 2007
  • MS, Dhaka University, 1997
  • B Pharm, Dhaka University, 1995      

PhD Thesis

Efficient elimination of multidrug-resistant Staphylococcus aureus by cloned lysin derived from bacteriophage  MR11           

Publications

  • Rashel M, Alston N and Soosan Ghazizadeh. Protein Kinase D1 Has a Key Role in Wound Healing and Skin Carcinogenesis. J Invest Dermatol. 2014 April; 134(4) 902-9.
  • Fukuda K, Ishida W., Uchiyama J, Rashel M,  Kato S.,  Morita T., Muraoka A.,  Sumi T, Matsuzaki S., Daibata M, and Fukushima A. Pseudomonas aeruginosa Keratitis in Mice: Effects of Topical Bacteriophage KPP12 Administration. PLoS One. 2012; 7(10): e47742
  • Uchiyama J, Rashel M, Takemura I, Ujihara T, Kato S, Muraoka A, Matuzaki S, Daibata M. Genetic craracterization of Pseudomonas aeruginosa bacteriophage KPP10. Arch Virol. 2012 Apr; 157(4):733-8.
  • Rashel M, Uchiyama J, Ujihara T, Takemura I, Hoshiba H, Matuzaki S. A novel site-specific recombination system derived from bacteriophage  MR11. Biochemical and Biophysical Research Communications. 368 (2008) 192-198.
  • Rashel M, Uchiyama J, Takemura I, Hoshiba H, Ujihara T, Takatsuji H, Koichi Honke, Matuzaki S. Tail-associated structural protein gp61 of Staphylococcus aureus phage MR11 has bifunctional lytic activity. FEMS microbiology letter 284 (2008) 9-16.
  • Rashel M, Uchiyama J, Ujihara T, Uehara Y, Kuramoto S, Sugihara S, Yagyu K, Muraoka A, Sugai M, Hiramatsu K, Honke K, Matuzaki S. Efficient elimination of multidrug-resistant Staphylococcus aureus by cloned lysin derived from bacteriophage  MR11. The Journal of Infectious Diseases.196 (15 October 2007):1237-1247.
  • Rashel M, Matuzaki S, and Uchiyama J. Pseudomonas phage KPP12, complete genome. NCBI Reference Sequence: NC_019935.1 (www.ncbi.nlm.nih.gov/nuccore/NC_019935.1).05-10-2010
  • Matuzaki S. and Rashel M. Pseudomonas phage KPP10, complete genome. NCBI Reference Sequence: NC_015272.1 (www.ncbi.nlm.nih.gov/nuccore/ NC_015272.1). 12-11-2008
  • Uchiyama J, Rashel M, Matsumoto T, Sumiyama Y, Wakiguchi H, Matsuzaki S. Characterization of a novel Pseudomonas aeruginosa bacteriophage PAJU2 which is genetically related to bacteriophage D3. Virus Res. 2009;139(1):131-4.
  • Nishikawa H, Yasuda M, Uchiyama J, Rashel M, Maeda Y, Takemura I, Sugihara T, Ujihara T, Shimizu Y, Shuin T, Matsuzaki S. T-even-related bacteriophages as candidates for treatment of Escherichia coli urianary tract infections. Archive of Virology 153 (2008) 507-515.
  • Uchiyama J, Rashel M, Maeda Y, Takemura Y, Sugihara S, Akechi K, Muraoka A, Wakiguchi H, Matsuzaki S. Isolation and  Characterization of a Novel Enterococcus faecalis bacteriophage  EF24C as a Candidate Therapeutic. FEMS Microbiology Letter s, 278 (2), 200-206, 2008.
  • Uchiyama J, Rashel M, Takemura I, Matsuzaki S. In Silico and In Vivo Evaluation of Candidate Therapeutic Bacteriophage  EF24C Against Enterococcus faecalis Infections. Applied and Environmental Microbiology 74 (2008) 4149-4163.
  • Matsuzaki S, Rashel M, Uchiyama J, Sakurai S, Ujihara T,  Kuroda M, Ikeuchi M, Tani T, Fujieda M, Wakiguchi H, Imai S.  Bacteriophage therapy?A revitalized therapy against bacterial infectious diseases. Journal of Infection and Chemotherapy, 11(5), 211-219, 2005.
  • Nasimuzzaman Md, Kuroda M, Dohono S, Yamamoto T, Iwatsuki K, Matsuzaki S, Rashel M,  Kumita W, Mizuguchi H, Hayakawa T, Nakamura H, Taguchi T, Wakiguchi H, Imai S. Eradication of Epstein-Barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNA1. Molecular Therapy, 11(4): 578-590, April, 2005.
  • Matsuzaki S, Rashel M, Kuroda M, Hoshiba H, Ujihara T, Akechi K, Uchiyama J, Sakurai S and Imai S. Bacteriophage therapy- A short review. Recent Research Development in Virology, 7, 1-11, 2005.
  • Matsuzaki S, Rashel M, Ujihara T, Akechi K and Imai S. Possibility and issue to be resolved in bacteriophage therapy. Medicine and Drug Journal, 40 (9): 2454-2459, November, 2004

Awards/Achievements

  • 2001-2006     Japanese Government Scholarship
  • 2005 "Award for the Best Young Researcher":4th Kochi Medical School Research Meeting

Affiliations

 AAAS, BAPA, New York Academy of Sciences

Contact

[email protected]
 

Cristina Maki Horimoto

Research at St. John’s (Sep 2013 – Dec 2013)
Enhancement of dissolution rate of poorly water soluble weakly acidic and basic drugs using weak counter-ions:

  • Basic amino acids are being used for increasing the dissolution rate of weakly acidic drugs;
  • Weak organic acids are being used for increasing the dissolution rate of weakly basic drugs.

Educational Background
Bachelor’s

  • St. John’s University, 2013 (2 semesters)
  • State University of Campinas (UNICAMP), 2009 -2014 (expected)

Internships         

  • Summer intern, Harvard School of Public Health, June – August 2013, Work related to genetics and toxicology assays.
  • Intern   Clinics Hospital – UNICAMP, February 2012, Activities related to screening of prescriptions, organization of the central pharmacy and pharmacovigilance.

Awards/Achievements

  • Scholarship (Brazilian federal government, CAPES, IIE): January – December 2013.

It is the Brazil Scientific Mobility Program – Science without Borders. One-year program to study abroad in a university in USA, with a required academic training during the summer, sponsored by Brazilian government.

Other research interests              

  • Pharmaceutical industry, pharmacology, toxicology, research and development, biotechnology

Contact 
[email protected]
[email protected]
LinkedIn: Cristina Horimoto

Niharika Sharma Penumaka

Sept 2013-May 2014

Educational Background

  • M.S., St. John's University, 2013
  • Registered Pharmacist - Pharmacy Council of Andhra Pradesh, India, May 2011 - March 2016
  • B. Pharm., Jawaharlal Nehru Technological University, 2010

Internships         

  • Intern, Venvet Chemicals Pvt Ltd., July 2010 - May 2011. Analysis and Assays of raw materials, assist supervisors, documentation.

Affiliations

  • AAPS Student Chapter - St. John's University, Pharmacy Council of Andhra Pradesh

Contact
[email protected]
LinkedInNiharika Sharma Penumaka

Tinne Monteyne

PhD/Doctoral  Student –IWT scholarship
Jan 2013-May 2013

Educational Background

  • Ph.D., Ghent University, September 2011- Present
  • M.S., Ghent University, Belgium 2009-2011
  • B. Pharm: Ghent University, Belgium 2006-2009.

Description of Research at St. John’s

  • Correlating off-line Rheological measurements to a continuous hot melt granulation process

Other Research Interests             

  • PAT
  • Granule & tablet characterization
  • Process optimization

Contact
[email protected]
LinkedIn: Tinne Monteyne

Yining Shao

Undergraduate Student

Research at St. John’s (Jun 2013- Sep 2013)

  • Solid dosage forms design, with a focus on properties of silicates and using them as a loading medium for self-emulsifying delivery systems.  Analysis of the lipid carrying potential of various silicates and meta-silicates with respect to their physical properties.

Educational Background

  • Bachelor’s/PharmD, St. John’s University, 2008 to 2014
  • Work Experience
  • Pharmacy Intern, CVS/Caremark, Nov 2011 to Present

Publication

  • “The epidermal growth factor tyrosine kinase inhibitor AG1478 and erlotinib reverse ABCG2-mediated drug resistance” Oncology Reports, Volume 21.  Number 2, Page 483-489.

Affiliations

  • ASHP, APhA-ASP, Rho Chi

Contact
[email protected]

Marilia de Lima Cirqueira

Research Scholar

Research at St. John’s (Aug 2013-Dec 2013)

  • Development and structure characterization of co-crystals of basic drugs with weak acids

Educational Background: 

  • Bachelor in Pharmacy, Federal University of Goias, Brazil. Graduation date: 2015
  • Non-degree one year International Student, St. Johns University, 2013-2014.

Honors:

  • Brazil Scientific Mobility Program recipient (full scholarship for a year)
  • X Award of Scientific Initiation of the Federal University of Goias – 2012

Other research interests

  • Salt formation for improved bioavailability
  • Monocrystal X-ray crystallography
  • Molecular biology

Publications:

  • Da Silva C. C., Cirqueira M. L., Martins F. T.  Lamivudine salts with 1,2-dicarboxylic acids: a new and a rare synthon with double pairing motif fine-tuning their solubility. CrystEngComm (Cambridge. Online)., v.15, p.6311 - 6317, 2013.
  •  De Melo A. C. C., De Amorim, I. F., Cirqueira, M. L., Martins, F. T. Toward novel solid state forms of the anti-HIV drug efavirenz: from low screening success to cocrystals engineering strategies and discovery of a new polymorph. Crystal Growth & Design. , v.13, p. 1558–1569 - , 2013.
  •  Da Silva C. C., Coelho, R. R, Cirqueira, M. L., De Melo A. C. C., Rosa I. M. L., Ellena, J., Martins, F. T. Salts of the anti-HIV drug lamivudine with phthalic and salicylic acids. CrystEngComm (Cambridge. Online)., v.14, p.4562 - 4566, 2012.

Contact:
[email protected]

 

Prajwal Thool

Masters Student

Educational Background

  • M.S., College of Pharmacy and Health sciences, St. John’s University Jan 2012-In progress
  • B. Pharm, Sharad Pawar College of Pharmacy, June 2010

Other research interests             

  • Compaction Technology
  • Lipid Based Delivery Systems
  • Oral delivery of proteins and peptides

Contact
[email protected]

Industrial Pharmacy Innovation Laboratory, Facilities & Equipment
The Industrial Pharmacy Innovative Laboratory was built in 2011 with generous donations from alumni and friends.  It is equipped with modern state of the art equipment for drug delivery research and pharmaceutical processing.

Facilities

Space

  1. Laboratory G9 (St. Albert’s Hall), 650 sq. ft.
  2. Laboratory B2 (St. Albert’s Hall), 1100 sq. ft.

Analytical Equipment

  • HPLC (7): Agilent 1100 series HPLC (2), Waters Corporation HPLC (5)
  • Dissolution Apparatus (2): Distek Inc.
  • High-speed centrifuge: Beckman GS6R
  • Particle size/zeta potential analyzer: Beckman Coulter, Delsa Nano, Dynamic Light scattering particle size analyzer
  • Viscometer: Brookfield, DVR-2 Viscometer
  • Rheometer: TA Instruments, Discovery HR-2 Hybrid Rheometer
  • Polarizing microscope: Nikon Eclipse 50i Polarized Light Microscope
  • Powder X-ray diffractometer: Shimadzu, X Ray Diffraction - XRD 6000
  • Differential scanning calorimeter: TA Instruments, DSC Q 200
  • Thermogravimetric analyzer: TA Instruments, TGA Q 50
  • Hot-stage microscope: Mettler Toledo FP82 Hot Stage Microscope
  • Pycnometer: Micromeretics Inc., Accupyc II 1340 Gas Pycnometer
  • Instron 4502 Material Testing System
  • Vanderkamp 1000 & Dr. Scheluniger  Pharmatron Hardness testers, Erweka Friability Apparatus, Vanderkamp Tapped Density Tester.

Process Equipment

  • Melt extruder: Thermo Scientific, Process 11, Hot Melt Extruder
  • Spray dryer: Buchi, B-90 Nano Spray Dryer
  • Tablet press – Shanghai Tiangfeng,  TDP Series, Single Punch Tablet Press
  • Rotary tablet press: Cadmach Machinery, Benchtop Rotary Tablet Press 8 Station
  • Fluid bed dryer and wurster coater:  VFC-LAB Micro FLO-COATER® Bench Top Fluid Bed System
  • Roller compactor: Mendel Company, MRC-5, Roller Compactor
  • Mill – Mendel Company, MRC-5, Oscillating Mill
  • Carver Tablet Press, Single station Model C
  • Mixers: Turbula, Planetary and V Blender
  • Coating: Shanghai Tiangfeng , Waternut Type Tablet Film Coating machine

Other equipment such as SEM, TEM, FTIR, Confocal Fluorescence Microscope, etc., isavailable in the department for use.

Publications

Prajapati H, Patel D, Patel N, Dalrymple D, Serajuddin ATM. Effect of Difference in Fatty Acid Chain Lengths of Medium-Chain Lipids on Lipid-Surfactant-Water Phase Diagrams and Drug Solubility. Journal of Excipients and Food Chemicals. 2011; 2(3):73-88.

Patel D., Prajapati H., Patel N., Dalrymple D., Serajuddin ATM. Effect of Difference in Fatty Acid Chain Lengths of Medium-Chain Lipids on Lipid-Surfactant-Water Phase Diagrams and Drug Solubility. Journal of Excipients and Food Chemicals. 2011; 2(3):73-88.

Prajapati H, Dalrymple D, Serajuddin ATM. A Comparative Evaluation of Mono-, Di- and Triglyceride of Medium Chain Fatty Acids by Lipid/Surfactant/Water Phase Diagram, Solubility Determination and Dispersion Testing for Application in Pharmaceutical Dosage Form Development. Pharm Res. (2012) 29:285–305

Patel N, Prajapati H, Dalrymple D, Serajuddin ATM. Development of Solid SEDDS, II: Application of Acconon C-44® and Gelucire 44/14® as Solidifying Agents for Self-emulsifying Drug Delivery Systems of Medium Chain Triglyceride. Journal of Excipients and Food Chemicals. 2012; 3(2):54-66

Shah AV, Serajuddin ATM. Development of solid self-emulsifying drug delivery system (SEDDS) I: use of poloxamer 188 as both solidifying and emulsifying agent for lipids. Pharm Res. 2012;29(10):2817-2832.

Patel D., Li.P., Serajuddin ATM. Enhanced microemulsion formation in lipid-based drug delivery systems by combining mono-esters of medium chain fatty acids with di- or tri-esters. J. Excipients and Food Chem. 3 (2) 2012

Patel N., Dalrymple D., Serajuddin A. Development of Solid SEDDS, III: Application of Acconon® C-50 and Gelucire® 50/13 as both solidifying and emulsifying agents for medium chain triglycerides. Journal of Excipients and Food Chemicals, North   America, June 2012.

Singh S, Parikh T,  Sandhu HK, Shah NH,  Malick AW, Singhal D, Serajuddin ATM. Supersolubilization and Amorphization of a Model Basic Drug Haloperidol by Interaction with Weak Acids, Pharm Res, 2013 Pharm Res Vol. 30, issue 6 (June 2013), p. 1561 – 1573.

Gumaste SG, Pawlak SA, Dalrymple DM, Nider CJ, Trombetta LD, Serajuddin ATM. Development of Solid SEDDS, IV: Effect of Adsorbed Lipid and Surfactant on Tableting Properties and Surface Structures of Different Silicates. Pharm Res 2013 Jun 26; DOI 10.1007/s11095-013-1114-4

Gumaste SG, Dalrymple DM, Serajuddin ATM. Development of Solid SEDDS, V: Compaction and Drug Release Properties of Tablets Prepared by Adsorbing Lipid-Based Formulations onto Neusilin® US2. Pharm Res. 2013 Jun 25 DOI 10.1007/s11095-013-1106-4

Gupta, S. S., Parikh, T., Meena, A. K., Mahajan, N., Vitez, I., & Serajuddin, A. T. (2014). Effect of Carbamazepine on Viscoelastic Properties and Hot Melt Extrudability of Soluplus®. International Journal of Pharmaceutics, Volume 478, Issue 1, 15 January 2015, Pages 232–239 The other JEFC publications are published.

Parikh, T., Gupta, S. S., Meena, A., & Serajuddin, A. T.M. Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion, III: polymethacrylates and polymethacrylic acid based polymers, Journal of Excipients and Food Chemicals, 2014, 5 (1), 56 - 64

Meena, A., Parikh, T., Gupta, S. S., & Serajuddin, A. T.M. Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion, II: Cellulosic polymers, Journal of Excipients and Food Chemicals, March 14, 2014, 5 (1), 46 - 55

Gupta, S. S., Meena, A., Parikh, T., & Serajuddin, A. T.M. Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion, I: Polyvinylpyrrolidone and related polymers, Journal of Excipients and Food Chemicals, 5 (1), 32 – 45, March 11, 2014

 

Podium Presentations

Development of Lipid Based Self Emulsifying Tablets by Adsorption of Microemulsion Preconcentrates on Neusilin® US2, presented by S. Gumaste at the 2012 AAPS—NERDG Annual Conference, Rocky Hill, CT, Apr 2012

Development of Solid SEDDS using Lauroyl- and Stearoyl - polyoxylglycerides as Solidifying Agents for Liquid Self-Emulsifying Formulations of Triglycerides, presented by H. Prajapati at the 2012 AAPS—NERDG Annual Conference, Rocky Hill, CT, Apr 2012

Formulation Development Strategy for Lipid-Based Drug Delivery of Poorly Water-Soluble Drugs, presented by A. Shah at ABITEC Learning Solutions: Oral Drug Delivery - Basel, Switzerland and Frankfurt, Germany, Oct 2012

Formulation Development Strategies for Solid Microemulsion Preconcentrates, presented by A. Shah at ABITEC Learning Solutions: Oral Drug Delivery - Basel, Switzerland and Frankfurt, Germany, Oct 2012

Viscosity and Extrudability of Selected Polymers in Presence of Drug, presented by S. Gupta  at Case Western Reserve University, Cleveland, OH, Jan 2013

Role of Physico-Chemical properties of polymers in Hot melt Extrusion, presented by T. Parikh at the 2nd Enhancing Drug Bioavailability and Solubility Conference, Boston, MA, Jan 2013

Application of film casting technique to predict drug polymer miscibility and physical stability of hot melt extrudates, presented by T. Parikh at the NERDG-ARA Conference, Rocky Hill, CT, Apr 2013

Practical Strategies for the Development of Self-Nanoemulsifying Drug Delivery Systems for Poorly Water- Soluble Drugs, presented by A. Shah at the 7th Annual Jarowski Industrial Pharmacy Symposium, St. John’s University, NY, Jun 2013

 

Poster Presentations:

Development of solid self-emulsifying lipid based drug delivery systems using poloxamer 188, a non- ionic block copolymer, as solidifying agent

Comparative Study of Propylene Glycol Monoester, Propylene Glycol Diester and Triglyceride Forms of Medium Chain Fatty Acids for Their Effects on Nanoemulsion Formation and Drug (danazol) Solubility.

To investigate effect of the fatty acid chain length on Nanoemulsion Formation and Drug Solubility.

A Comparative Evaluation of Mono-, Di- and Triglyceride of Medium Chain Fatty Acids by Lipid/Surfactant/Water Phase Diagram, Solubility Determination and Dispersion Testing for Application in Pharmaceutical Dosage Form Development 

Characterization of Medium Chain Fatty Acids for Nanoemulsion Formation and Drug Solubility. I. Comparative Study of Mono-, Di- and Tri-Glycerides.

Systematic Study of Effects of Mono-, Di- and Tri Glycerides of Medium Chain Fatty Acids on Development of Lipid-based Drug Delivery Systems.

Effect of Fatty Acid Chain Length in Propylene Glycol Mono- and Di-ester Lipids on Micro- and Nano-emulsion Formation and Drug Solubility.

Effect of Difference in Fatty Acid Chain Length of Medium-Chain Lipids on Drug Solubility and Lipid-Surfactant-Water Phase Diagrams

Formulation and Characterization of Novel Solid Microemulsion Preconcentrate System for Application in Pharmaceutical Dosage Form Development.

Formulation and Characterization of Solid Microemulsion Preconcentrate System for Medium Chain Triglyceride Using Lauroyl Macrogolglycerides as Solidifying agents

Construction of a Ternary Phase Diagram of a Poorly Water Soluble Drug in Presence of Hydrophilic Polymer and a Surfactant: Itraconazole, Soluplus® and Kolliphor® P 188

Thermal and viscoelastic properties of Polymers Relevant to Hot Melt Extrusion

Dissolution Enhancement of Ziprasidone HCl Using Hot Melt Extrusion

Effect of Presence of Drugs on Viscoelastic Properties and Extrudability of Soluplus®, a Graft Copolymer

Application of film casting technique to predict drug polymer miscibility and physical stability of hot melt extrudates

Development of amorphous solid dispersion of itraconazole using weak organic acids

Effect of Drug Concentration and Processing Temperature on Extrudability and Miscibility of Solid Dispersions by Hot Melt Extrusion

Ankita Shah​​

Doctoral Student

Post Doctoral Student

Educational Background

  • Ph.D., St. John’s University,Queens, NY, 2016
  • M.S., St. John’s University, Queens,  NY, 2011
  • Bachelor of Pharmacy, L. M. College of Pharmacy, India, 2008

Ph.D. Thesis

  • Dissolution enhancement of poorly water soluble weakly acidic and basic drugs using non-salt forming counter ions

M.S. Thesis

  • Development of solid self-emulsifying drug delivery system (SEDDS) I: use of poloxamer 188 as both solidifying and emulsifying agent for lipids

Publications      

  • Shah AV, Serajuddin ATM. Development of solid self-emulsifying drug delivery system (SEDDS) I: use of poloxamer 188 as both solidifying and emulsifying agent for lipids. Pharm Res. 2012;29(10):2817-2832.
  • Shah A, Serajuddin ATM. Conversion of solid dispersion prepared by acid-base interaction into free-flowing and tabletable powder by using Neusilin® US2, Submitted for publication.
  • Shah A, Serajuddin ATM. Supersolubilization by using non-salt forming acid-base interaction. In: Shah N, Sandhu H, Choi DS, Chokshi H, Malick AW (Eds.), Amorphous solid dispersions. Springer, New York, 2014.

Podium Presentations

  • Practical Strategies for the Development of Self-Nanoemulsifying Drug Delivery Systems for Poorly Water- Soluble Drugs,   7th Annual Jarowski Industrial Pharmacy Symposium, St. John’s University, NY   June 2013
  • Formulation Development Strategy for Lipid-Based Drug Delivery of Poorly Water-Soluble Drugs & Formulation Development Strategies for Solid Microemulsion Preconcentrates, ABITEC Learning Solutions: Oral Drug Delivery, Basel, Switzerland, October 17, 2012 & Frankfurt, Germany, October 18, 2012

Poster Presentations

  • Dissolution Enhancement of Ziprasidone HCl Using Hot Melt Extrusion, 7th Annual Jarowski Industrial Pharmacy Symposium, St. John’s University, NY, June 2013
  • Development of solid self-emulsifying lipid based drug delivery systems using poloxamer 188, a non- ionic block copolymer, as solidifying agent, 2011 AAPS-NERDG Annual Meeting, Rocky Hill, CT, April 2011
  • Development of solid self-emulsifying lipid based drug delivery systems using poloxamer 188, a non- ionic block copolymer, as solidifying agent, 2010 FIP PSWC and AAPS Annual Meeting, New Orleans, LA, November 2010

Awards

  • "Travelship Award", New Orleans, LA- AAPS Annual Meeting and Exposition, 2010

Other Research Interests

  • Effect of microenvironmental pH on dissolution of weakly basic drugs and their salts
  • Solid dispersion by hot melt extrusion technology
  • Lipid based drug delivery systems
  • Cocrystals

Contact
[email protected]
[email protected]
Linkedin: Ankita Shah