Enju Wang

Chemical sensors are extremely important tools for monitoring chemical species in biological systems, environmental situations, and chemical processes. Optical sensors offer further advantages such as freedom from electrical interference, ease of miniaturization and ability to perform remote sensing. In particular, sol-gel glass is well suited as a support matrix for chemical sensors because of its excellent optical clarity, and its ability to be cast as thin films. Molecular imprinting process technology also offers promising technology for developing high selective/specific binding materials for chemical sensing, separation and sample clean up.

Current research focuses on investigating new configurations and materials for the sensing and detection of macromolecules, bacteria, ions, small molecules and gases. For example, we have developed sensors for heparin, protamine, imidazole, potassium, chloride, urea, methyl amine, and ammonia. Our research is also directed at developing separation protocols for important drugs, such as chiral separation of ibuprofen, synergistic anticancer drugs paired with Doxorubicin.  

     Zeng, L.; Gupta, P.; Chen, Z.-S.; Chen, Y.; Wang, E.; Ji, L.; Chao, H. The Development of Anticancer Ruthenium(Ii) Complexes: From Single Molecule Compounds to Nanomaterials. Chem. Soc. Rev. 2017, No.              Copyright (C) 2017  U.S. National Library of Medicine.

     Tan, Y.; Escorcia, N.; Hyslop, A.; Wang, E. Investigation of Cobalt Porphyrin Doped Polymer Membrane Films for the Optical Sensing of Imidazole and Its Derivatives. Anal. Chem. Res. 2015, 3 (Copyright (C) 2017      American Chemical Society (ACS). All Rights Reserved.), 70–76.

Yixi Xie, Yu Lei,  Shalini Shah, Hao Wu, Jian Wu, Elise Megehee, and Enju Wang*. “Investigation of Luminescence Characteristics of Osmium(II) Complexes  in the Presence of Heparin Polyanions.” International Journal of Analytical Chemistry, Volume 2013, Article ID 419716, 8 pages.

Hao Wu, Jian Wu, Christopher Saez, Maria Campana, Elise Megehee and Enju Wang*, “Study of Luminescence Osmium Complex Response to Macromolecular Polyanions for the Detection of Heparin and Chondroitin Sulfate in Biomedical Preparations” Anal. Chim. Acta.  Volume 804, 4 December 2013, Pages 221–227. 

Wenqun Wang, Kwok-Fan Chow, Alvin Persad, Enju Wang*, Ann Okafor, Neil Jespersen, “Investigation of Dye Doped Sol-gels for the Optical Sensing Towards Aliphatic Amines,”  The Sol-gel Process: Uniformity, Polymers and Applications, P631-644. Nova Science Publishing, 2010.

Zhiling Wang, Enju Wang, Shuxiang, Zheng Wang and Yiping Ren, “Effect of cross-linking on mechanical and physical properties of agricultural residues/recycled thermoplastics composites”,  Industrial Crops and Products 29, (2009) 133-138.

Alvin Persad, Kwok-Fan Chow, Wenqun Wang, Enju Wang, Ann Okafor, Neil Jespersen, Jonathan Mann and Andrew Bocarsly, “ Investigation of Dye Doped Sol–Gels for Ammonia Gas Sensing,” Sensors and Actuators, 129B (2008) 359-363.

      Enju Wang, Kwok-Fan Chow, Crystal Wong, Cindy Yee, Alvin Persad, Jonathan Mann and Andrew Bocarsly+, “Optical Sensing of HCl With Phenol Red Doped Sol-Gels,” Analytica Chemica Acta,  534, 301-306 (2005).

Enju Wang, Kwok-Fan Chio, Vivian Kwan, Tammy Chin, Crystal Wong and Andrew Bocarsly, “Fast and Long Term Optical sensors for pH Based on Sol-Gels,”  Analytical Chimica Acta.  495, 45-50 (2003).

      Enju Wang, Carlos Romero, Darran Santiago and Vayia Syntilas, “ Optical Anion sensing characteristics of indium-porphyrin and lipophilic dichlorofluorescein doped polymer films”, Analytica Chemica Acta, 2001, 433, 89-95.

     Hongmei Chen and Enju Wang, “Urea Optical sensors based on Ammonium Ion Selective Polymer Membranes.” Analytical Letters, 33, 997-1011 (2000).

Enju Wang and Satuo Kamata, Optical sensors for OH^- and Cu²⁺ Based on 8-hydroxyquinoline derivatives, Kagoshima Daigaku Kogakubu Kenkyu Hokoku, 41, 1499-151 (1999).

Enju Wang,  Hongmei Chen, Hema Patel, Ishwar Sadarangani and Carlos Romero, “Influence of Nonionic Surfactants on the Optical Response of Cation Selective Membrane Films.“ Analytica Chimica Acta 397, 287-294 (1999).

Enju Wang, Lin Zhu, Leanne Ma and Hema Patel, “Optical Sensors for Sodium, Potassium and Ammonium Ions Based on Lipophilic Fluorescein Anionic Dye and Neutral Carriers.” Analytical Chimica Acta 357, 85-90 (1997).

Enju Wang, Leanne Ma, Lin Zhu and Christopher M. Stivanello, “Calcium Optical Sensors Based on Lipophilic dichlorofluorescein Anionic Dye and  Calcium Organophosphate Ionophore or Neutral Carriers.” Anal. lett. 30 (1), 1997

B. Fu, E. Bakker, J. H. Yun,  E. Wang, V. C. Yang and M.E. Meyerhoff, “Polymer Membrane-Based Polyion Sensors: Development, Response Mechanism,and Bioanalytical Applications.” Electroanalysis 1995, 7, 823-829.

Enju Wang, Guozhi Wang, Leanne Ma, Christopher M. Stivanello, Samantha Lam and Hema Patel, “Optical Films for Protamine Detection with Lipophilic Dichlorofluorescein Derivatives," Anal. Chim. Acta, 334, 139-147 (1996).

E. Wang, M. E. Meyerhoff and V. C. Yang, “Optical Detection of Macromolecular Heparin via Selective Coextraction into Thin Polymeric Films.” Anal. Chem. 1995, 67, 522-527.

E. Wang and M. E. Meyerhoff, “Anion selective optical sensing with metalloporphyrin-doped      polymeric films.” Anal. Chim. Acta, 1993, 283, 673-678.

E. Wang and M. E. Meyerhoff, “Evaluation of polyurethane-based membrane matrices for optical ion-selective sensors.” Anal. Lett. 1993, 26(7), 1519-1533

E. Wang, K. Ohashi and S. Kamata, “Optical sensing properties of PVC membrane incorporating lipophilic 8-hydroquinoline derivative.”  Chem. Lett., 1992, 939-942.

E. Wang, and S. Kamata, “Potentiometric flow analysis device using membrane- coated carbon rod ion-selective electrode detectors.”  Anal. Chim. Acta, 1992, 261, 399-404.

E. Wang, K. Ohashi and S. Kamata, “Coated carbon-rod anion electrodes using    bis(diphenylphosphino)propane-metal complexes.” Anal. Sci. 1991, 7, 755-756.

U. Oesch, E. Wang, E. Malinowska and W. Simon, “Determination of blood bicarbonate with a single ion-selective electrode.”  Methodology and clinical applications of electrochemical and fiber optical sensors, 1989, 11, M14. 47-61.

E. J. Wang and T. R. Yu, “Diffusion of ions in variable-charge soils. 3. Simultaneous diffusion of ions in mixed-salt systems.”  Soil Sci., 1989, 147 (3), 174-178.

E. J. Wang and T. R. Yu, “Diffusion of ions in variable-charge soils. 2. Effect of soil surface charge on diffusion coefficients of cations and anions.”  Soil Sci., 1989, 147 (2), 91-96.

E. J. Wang. and T. R. Yu, “Diffusion of ions in variable-charge soils. 1. Determining diffusion coefficients with miniature ion-selective electrodes.”  Soil Sci., 1989, 147 (1), 34-49.

E. Wang, “Mini-type liquid ion-selective electrodes for soil sample applications.”  Proc. 5th Conf. on Chem. Sens., 1986.

T. Sun, E. Wang and N. Liu, “The design and performance of Co(II) ion-selective electrodes.”  Shandong Normal University Acta, 1984, 3(4), 28-31.

Enju Wang, etal, Dye Doped Sol-gels for the Optical Sensing towards Aliphatic Amines. In “The Sol-Gel Process: Uniformity, Polymers and Applications, Editor: Rachel E. Morris, Nova Publishers, NY. Fall  2010.

Enju Wang, Optical Sensors/Optrodes, Chapter 21 in Modern Instrumental Analysis, Vol 47, Ed. By Sut Ahija and Neil D. Jespersen. Elsevier, Amsterdam, Dec. 2006.

Yu, T. R.; and Wang, E. J., Ion Diffusion in Chemistry of Variable Charge Soils, (1997),  p309-338. Oxford University Press.

Maria Campana and  Enju Wang^, High Performance Enantioselective Chiral Separation of Racemic Ibuprofen by Hydroxypropyl-β-cyclodextrin, Presented at Fall 2014 ACS meeting, San Francisco, Aug 11, 2014.

Christopher Saez and Enju Wang, Development of a Novel Separation Method of Anticancer Drugs Using Reverse Phase High Performance Liquid Chromatography Presented at Fall 2014 ACS meeting, San Francisco, Aug 11, 2014.

A. Okafor, Enju Wang, N. Jespersen, V. Sococco and S. Sadoqi,  Effect of a Fluorophore on Bovine Serum Albumin Using Molecular Imprinting Process, Presented as a Poster at Eastern Analytical Symposium, Nov. 19, 2013, Somerset, NJ.

Yueyang Tan and Enju Wang, Investigation of Co(III)porphyrin doped polymer membranes for the optical sensing towards imidazole. Presented at the 244^th ACS meeting, Philadelphia, August, 2012.

Viviana Scocco, Ann Okafor and Enju Wang, Molecular imprinted fluorescence sensor for oil dibenzothiophene (DBT) detection. Presented at the 244^th ACS meeting, Philadelphia, August, 2012.

Anne Geller, Natalie Byfield, Zachary Davis, Emilio Squillante, Jennifer Travis, Melissa Yates and Enju Wang,  At Home with Writing, WAC Faculty Fellows at St. John’s University. 10^th International Writing Across the Curriculum conference, Indiana University, Bloomington, IN. May 20-22, 2010.

Enju Wang, “Spectroscopic studies on the Interaction of Polyanions with Osmium(II) complexes, ACS  meeting, Washington DC, August 2009.

Enju Wang “Fluorimetric determinations of nucleic acids, anions, and oxygen using osmium complexes. Cordon Research Conference on Biosensors, 2008, RI.

Yu Lei, Yixi Xie, Enju Wang and Elise Megehee, determinations of nucleic acids, anions, and oxygen using osmium complexes’, Pittcon 2008, Feb.  2008, New Orleans.

Yu Lei, Brian Xie, Enju Wang, Pentea Manhaji, Elise Megehee, Ann Okafor, Neil Jespersen, “New Os-complexes as Fluorophores for DNA Detection and Oxygen Sensing,” 234th ACS National Meeting, Boston, MA, August 19, 2007.

Anne Okafor, Enju Wang, Neil Jespersen and Mostafa Sadoqi, “Selective Detection of DPA”, Presented at EAS-07, Nov. 14, Somerset, NJ.

Okafor Anne, Wang Enju, Joseph Serafin, Jespersen, D. Neil, Chow Kwok-Fan, Wang Wenqun, and Shen Fangfei, “Evaluating Sol-Gel Precursors For High Acidity Measurements,” presented at the Eastern Analytical Symposium, Somerset, NJ, Nov, 17, 2006.

Anne Okafor, Wenqun Wang, Kwok-Fan Chow, Crystal Wong, Cynthia Yee, Enju Wang and Neil D. Jespersen. “Dye Doped Sol-gels for Chemical Sensors, ”To be presented at Pittcon-05 (Invited oral presentation), Orlando, Florida, March, 2005. Invited.

Enju Wang, “Development of Optical sensors based on sol-gels and polymer membranes, ”Invited talk at Brooklyn College, CUNY, October 29, 2004.

Wenqun Wang,  Alvin Persad, Kwok-Fan Chow, Crystal Wong, Cynthia Yee, and Enju Wang, “Optical sensors for amine based on dye-doped sol-gels. Will be presented at EAS-04, Somerset, NJ.   

Enju Wang,  Kwok-Fan Chow, Crystal Wong , Vivian Kwan, Tammy Chin, and Andrew Bocarsly.  Optical Sensors for HCl and HNO₃ Based on Phenol Red Doped in Sol-Gels,” Invited oral presentation at Pittcon, March, 2004, Chicago, IL.  

Enju Wang and Andrew Bocarsly, Optical sensors for pH and Other ions Based on Sol-Gels,     Presented at Eastern Analytical Symposium 2002, Somerset, NJ Nov, 20, 2002.  

Kwok-Fan Chio and Enju Wang. Optical Sensing of Micromolecular Heparin and Other Polyanions with Thin Polymeric Films, Presented at EAS 2001, Atlanta, NJ, Nov, 2001.  

Enju Wang, Optical Sensors Based on Thin Polymer films for Heparin Detection, Invited talk at Emisphere Technologies, Inc., 765 Old Saw Mill River Road, Tarrytown, NY. Jan. 17, 2001.

Title; Optical membrane films for polycation detection, Serial No. 09/032,503.  US Patent Office on Dec. 22, 1999.

Summer research support, St. John's University, Summers 1994-1997, 1999 and 2001

Faculty Merit Award, St. John's University, September 1998, 1999, 2000, 2001, 2004, 2005, 2014.

Research Reduction, St. John's University, 1993-2001, 2004-2005, 2007

Best America Professors Who’s Who Award, 2004.

Outstanding faculty award, St. John’s University, June 2005.

Research Leaves, 2001-2002 and Fall 2008.

Title: Incorporation of Computer Modernized Cary-14 UV-Vis Spectrophotometer in the Undergraduate Curriculum, Submitted to National Science foundation in June 5, 2000, with Drs Hyslop, Megehee, Rosso and Jespersen. Amount Requested: $81,501. 2002 to 2005.

Stipend Awarded for research leave from Bristol-Myer-Squib for 01/02. Award Amount: $36,000.

Title: Titrametric Determination of Heparin in Whole Blood. Submitted to National Institute of Health, April, 1997. In collaboration with Dr. Glenn Martin at STI (Ann Arbor, MI). Amount requested: $29,257. 1997-  Dec. 1998.

Title: Development of Fiber-Optical Sensors for Bioanalytical Applications, Submitted to NIH for Minority Student Research Program, Feb., 1, 1997. Status: funded for two students working in the lab, lab supplies for $3,000, and $ 1,600 to attend meetings each year for 3 years.

Che 1100, College chemistry

Che 1210/1211R, General chemistry

Che 3250/3251L, Quantitative chemical analysis

Che 3300/3301L, Instrumental analysis

Che 101/101L, Modern Instrumental analysis

Che 202, Separation science and technology

Che 268, Modern Chemical and Bio-Sensor Technology

ACS member, EAS board member,

Graduate policy committee member, St. John’s University

Reviewer for NSF, NIH, DOE grants.

Reviewer for Anal. Chem, Anal. Chim, Acta, Analyst, Talanta, Sen.&Actuators, B Chemical etc. Journals.