Xingguo Cheng

Dr. Cheng is currently an Associate Professor in the Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University. Dr. Cheng received Ph. D. degree (major in Toxicology) from University of Kansas Medical Center (Kansas City, KS). Primary goal of ongoing research in Dr. Cheng’s laboratory is to characterize how to improve liver function and prevent drug-induced liver injury. Dr. Cheng published research articles in the peer-reviewed journals such as Drug Metabolism and Disposition, Molecular Pharmacology, Biochemical Pharmacology, Journal of Pharmacology and Experimental Therapeutics, Toxicology, Toxicological Sciences, Toxicology and Applied Pharmacology, and Journal of Biological Chemistry. Dr. Cheng received internal University grants, industry grant, and private research funds to support the research in his laboratory.

Teaching Interests

Toxicology Biochemistry

Research Interests

Toxicology/pharmacology; Toxicokinetics; Toxicodynamics

Courses Taught

PHS 2201 BIOPHARMACEUTICAL CHEMISTRY

TOX 215 ANALYTICAL METHODS TOXICOLOGY

TOX 230 TOXICOLOGY JOURNAL CLUB

TOX 4413 ANALYTICAL & QUANTITATIVE TOX

Select Publications

Journal Articles

Le , Y., Chen, L., Zhang, Y., Bu, P., Dai, G., and Cheng, X. (2018). Epalrestat Stimulated Oxidative Stress, Inflammation and Fibrogenesis in Mouse Liver.. Toxicological sciences : an official journal of the Society of Toxicology. vol. 163, pp. 397-408.

Zhang, Y., Zhang, Y., Klaassen, C. D., and Cheng, X. (2018). Alteration of bile acid and cholesterol biosynthesis and transport by perfluorononanoic acid (PFNA) in mice.. Toxicological sciences : an official journal of the Society of Toxicology. vol. 162, pp. 225-233.

Bu, P., Le , Y., Zhang, Y., Zhang, Y., and Cheng, X. (2017). Berberine-induced Inactivation of Signal Transducer and Activator of Transcription 5 Signaling Promotes Male-specific Expression of a Bile Acid Uptake Transporter.. The Journal of biological chemistry. vol. 292, pp. 4602-4613.

Vispute, S. G., Bu, P., Le , Y., and Cheng, X. (2017). Activation of GR but not PXR by dexamethasone attenuated acetaminophen hepatotoxicities via Fgf21 induction.. Toxicology. vol. 378, pp. 95-106.

Bu, P., Ji, Y., Narayanan, S., Dalrymple, D., Cheng, X., and Serajuddin, A. T. (2017). Assessment of cell viability and permeation enhancement in presence of lipid-based self-emulsifying drug delivery systems using Caco-2 cell model: Polysorbate 80 as the surfactant.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol. 99, pp. 350-360.

Rockwell, C. E., Turley, A. E., Cheng, X., Fields, P. E., and Klaassen, C. D. (2017). Persistent alterations in immune cell populations and function from a single dose of perfluorononanoic acid (PFNA) in C57Bl/6 mice.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol. 100, pp. 24-33.

Bu, P., Narayanan, S., Dalrymple, D., Cheng, X., and Serajuddin, A. T. (2016). Cytotoxicity assessment of lipid-based self-emulsifying drug delivery system with Caco-2 cell model: Cremophor EL as the surfactant.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol. 91, pp. 162-71.

Bu, P., Le , Y., Zhang, Y., and Cheng, X. (2016). Hormonal and Chemical Regulation of the Glut9 Transporter in Mice.. The Journal of pharmacology and experimental therapeutics. vol. 360, pp. 206-214.

Cheng, X., Gu, J., and Klaassen, C. D. (2014). Adaptive hepatic and intestinal alterations in mice after deletion of NADPH-cytochrome P450 Oxidoreductase (Cpr) in hepatocytes.. Drug metabolism and disposition: the biological fate of chemicals. vol. 42, pp. 1826-33.

Hou, W. Y., Xu, S. F., Zhu, Q. N., Lu, Y., Cheng, X., and Liu, J. (2014). Age- and sex-related differences of organic anion-transporting polypeptide gene expression in livers of rats.. Toxicology and applied pharmacology. vol. 280, pp. 370-7.

Cheng, X., Zhang, Y., and Klaassen, C. D. (2014). Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in increased bile acids in serum.. The Journal of pharmacology and experimental therapeutics. vol. 351, pp. 105-13.

Cheng, X., Vispute, S. G., Liu, J., Cheng, C., Kharitonenkov, A., and Klaassen, C. D. (2014). Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR).. Toxicology and applied pharmacology. vol. 278, pp. 65-71.