Woon-Kai Low

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Associate Professor
Pharmaceutical Sciences
College of Pharmacy and Health Sciences

Research Interests

Investigate the process of mRNA translation in eukaryotic cells. Explore therapeutic intervention for cancer that targets the translation initiation process using small molecules and derivatives of natural products. Recombinant protein production in prokaryotic and eukaryotic system.

Courses Taught

BIT 270 INTRO TO BIOTECHNOLOGY

PHS 270 INTRO TO BIOTECHNOLOGY

PHS 2201 BIOPHARMACEUTICAL CHEMISTRY

TOX 1401 MOLECULAR TOXICOGENOMICS

Select Publications

Fu, C., S. Gobbooru, A. T. Martino and W. K. Low (2024). "Production of VP3-only virus-like particles of Adeno-associated virus 2 in E. coli cells." Protein Expr Purif220: 106502.

Kommaraju, S. S., J. Aulicino, S. Gobbooru, J. Li, M. Zhu, D. Romo and W. K. Low (2020). "Investigation of the mechanism of action of a potent pateamine A analog, des-methyl, des-amino pateamine A (DMDAPatA)." Biochem Cell Biol98(4): 502-510.

Shao, X., S. Pak, U. K. Velagapudi, S. Gobbooru, S. S. Kommaraju, W. K. Low, G. Subramaniam, S. K. Pathak and T. T. Talele (2020). "Synthesis of 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxamide and 3-oxo-3,4-dihydrobenzo[b][1,4]oxazine-8-carboxamide derivatives as PARP1 inhibitors." Bioorg Chem102: 104075.

Agarwal, P., P. Khatri, B. Billack, W. K. Low and J. Shao (2014). "Oral Delivery of Glucagon Like Peptide-1 by a Recombinant Lactococcus lactis." Pharm Res.

Low, W. K., J. Li, M. Zhu, S. S. Kommaraju, J. Shah-Mittal, K. Hull, J. O. Liu and D. Romo (2014). "Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents." Bioorg Med Chem22(1): 116-125.

Patel, K., G. K. Shah, S. S. Kommaraju and W. K. Low (2014). "Investigation of the conserved glutamate immediately following the DEAD box in eukaryotic translation initiation factor 4AI." Biochem Cell Biol92(1): 33-42.

Kulkarni, S. S., S. Singh, J. R. Shah, W. K. Low and T. T. Talele (2012). "Synthesis and SAR optimization of quinazolin-4(3H)-ones as poly(ADP-ribose)polymerase-1 inhibitors." Eur J Med Chem50: 264-273.