Sandra E. Reznik

Professor
Pharmaceutical Sciences
M.D., Ph.D., Biomedical Sciences, Mount Sinai School of Medicine, 1991A.B., Biology, Harvard University, 1984

After graduating from Harvard, as a Medical Scientist Training Program student at the Mount Sinai School of Medicine (1984-1991), under the direction of Dr. Marian Orlowski, who was nominated for the Nobel Prize in 2004, I characterized the novel neuropeptide synthesizing enzyme Endopeptidase 24.15, aka thimet oligopeptidase. After obtaining my M.D. and Ph.D. degrees from Mount Sinai, I completed my residency in Anatomic Pathology at New York Hospital/Cornell University Medical College in 1994 and then two fellowships at the Montefiore Medical Center/Albert Einstein College of Medicine from 1996 to 1998. During my fellowship in perinatal pathology, I received a Mentored Clinical Scientist Development Award (K08 grant) in 1998 and remained at Einstein full-time until 2004, where I worked with Dr. Lloyd Fricker on several peptide processing enzymes in the Department of Molecular Pharmacology. I accepted a position as Associate Professor at St. John’s University in 2004 and became full professor at St. John’s in 2016. 

My laboratory is focused on inflammation-driven preterm birth. A few years ago, we made the fortuitous discovery that a commonly used drug excipient, N,N-dimethylacetamide (DMA), prevents endotoxin-induced preterm birth in our murine model. Further investigation has revealed that this compound is an unrecognized cytokine suppressive anti-inflammatory drug that inhibits nuclear factor kappa B. As the toxicokinetics of this widely used compound have already been well documented, including safety data related to its use during pregnancy, this molecule has now been recognized as an excellent candidate for clinical trials to prevent preterm birth. While my lab remains focused on preterm birth, we recognize that DMA, an NF-kappa B inhibiting small molecule that can cross the blood brain barrier, may have broad clinical impact. Preliminary testing has shown promising results in an in vivo model of inflammatory bowel disease and in in vitro models of rheumatoid arthritis and neuroinflammation.

Most recently the research program has expanded to embrace the investigation of environmental and dietary factors that lead to the inflammatory signature that triggers spontaneous preterm birth. In a very exciting new line of investigation, we have shown that immune tolerance established by repetitive exposure to subclinical doses of lipopolysaccharide reverses the lipotoxic effects of a high fat diet, including gut dysbiosis, and protects mice from preterm birth. Funding has recently been obtained to test Broncho-Vaxom, a clinically approved therapy, for its ability to reverse high fat diet induced gut dysbiosis and immune dysregulation.

  • NIH Pregnancy and Neonatology Study Section, Ad Hoc Member, 2008, 2009, 2016
  • Preterm Birth International Collaborative, Invited Member, 2018-
  • St. John’s University Faculty Recognition Awards for Research, 2010-2011, 2011-2012, 2012-2013, 2013-2014, 2014-2015, 2015-2016, 2016-2017, 2017-2018
     

NIH Grant: 5K08 HD 01209
Title:  Peptide Processing Enzymes in the Placenta
Dates:  April 1, 1998-April 30, 2002, October 1, 2003-February 28, 2005
Total Costs:  $425,790
Role: Principal Investigator  

NIH Grant: 1R01NS069577
Title: Cerebral Malaria:  Mechanisms of Disease and Neurological Salvage
Dates: April 15, 2011-April 14, 2016
Total Costs: (Sub-award) $297,000
Role: Co-Investigator

Lumara Health (AMAG) Research Grant Award
Title:  Investigation of the Anti-Inflammatory and Potential Tocolytic Activities of N, N-Dimethylacetamide-Related Compounds Using In Vitro and Ex Vivo Models
Dates:  December 1, 2015-November 30, 2016
Total Costs: $25,000
Role: Principal Investigator

Nassau Health Care Corporation Contract
Title:  Novel Approaches to Trauma-Induced Pro-inflammatory Responses
Dates: December 16, 2016-October 14, 2019
Total Costs: $45,000
Role: Principal Investigator

Vifor Pharma Grant
Title: OM-85 for the Reversal of High Fat Diet Induced Gut Dysbiosis
Dates: July 17, 2018-July 31, 2021
Total Costs: $150,000
Role: Principal Investigator

INVITED LECTURES

  • The Role of Endothelin-1 in Preterm Labor and Its Inhibition by Novel 1,3,6-Trisubstituted 4-Quinolone ETA Receptor Antagonists. American Chemical Society Address (2008).
  • From Mice to Microarrays:  Identifying the Key Players in Infection-Associate Preterm Birth. Department of Applied Sciences, Winthrop University Hospital, Mineola, NY Seminar (2010). 
  • The Mechanism of Action of Plan B.  Press Conference, Columbus, OH (2010).
  • The Mechanism of Action of Plan B.  Brown Bag Presentation to Ohio Legislature. (2010).
  • The Mechanisms of Action of Mifepristone, Ulipristal and Levonorgestrel. NARAL Pro-Choice New York / National Institute for Reproductive Health Teleconference.  (2010).
  • Dimethylacetamide Controls Infection-Associated Preterm Birth in a Murine Model:  An Accidental Discovery.  Department of Applied Sciences, Winthrop University Hospital Research Institute, Mineola, NY Seminar (2011).
  • Novel Approaches to Inflammation-Associated Preterm Birth. Department of Pediatrics, Feinstein Institute for Medical Research, Manhasset, NY Seminar (2015).
  • The Organ That Determines Our Future: Environmental Effects on the Placenta. CDC/NIOSH Seminar (2017).             
  • An Accidental Discovery: N,N-Dimethylacetamide and Its Analogs for the Prevention of Inflammation Driven Preterm Birth. Society for Reproductive Investigation’s Joint Preterm Birth International Collaborative and Myometrium/Parturition Satellite Symposium Lecture (2018). 
  • The Treasure Under Our Noses: N,N-Dimethylacetamide and Its Analogs for the Prevention of Preterm Birth. Preterm Birth International Collaborative North American Branch Inaugural Meeting Lecture (2018).

INTRAMURAL PRESENTATIONS:

  • Reznik SE and Montefiore Medical Center Pathology Residents, Neonatology Morbidity and Mortality Conferences, monthly presentations (1997-present).
  • Reznik SE.  Physiology and Pathology of the Placenta.  Annual Lecture presented to Albert Einstein College of Medicine medical students (1998-present).
  • Reznik SE.  Placental Pathology and the Perinatal Autopsy.  Annual Lecture presented to Montefiore Medical Center PGY1 residents (1998-present). 
  • From Mice to Microarrays:  Identifying the Key Players in Infection-Associated Preterm Birth.  St. John’s University Department of Biological Sciences Doctoral Seminar (2009).
  • Olgun NS, Patel HJ, Stephani R and Reznik SE.  Evaluation of Acute Toxicity of Novel Selective ETA Receptor Antagonists That Control Preterm Birth in a Mouse Model.  St. John’s University Faculty Research Forum, poster presentation (2009).        
  • Olgun N, Patel HJ, Stephani R and Reznik SE.  Evaluation of Acute Toxicity of Novel Selective ETA Receptor Antagonists That Control Preterm Birth in a Mouse Model.  St. John’s University Student Poster Day (2009).
  • Madankumar R, Munnangi S, Chen C-H, Yen H, Wang W, Gross SJ and Reznik SE.  Up-regulation of the Interleukin-1 Beta-Tumor Necrosis Factor Alpha Pathway in a Mouse Model of Infection-Associated Preterm Labor.  St. John’s University Faculty Research Forum, poster presentation (2009).
  • Olgun NS, Patel HJ, Stephani R and Reznik SE.  Evaluation of Acute Toxicity of Novel Selective ETA Receptor Antagonists That Control Preterm Birth in a Mouse Model.  St. John’s University Faculty Research Forum, poster presentation (2009).          
  • Madankumar R, Munnangi S, Chen C-H, Yen H, Wang W, Gross SJ and Reznik SE.  Up-regulation of the Interleukin-1 Betta-Tumor Necrosis Factor Alpha Pathway in a Mouse Model of Infection-Associated Preterm Labor.  St. John’s University Student Poster Day (2009).                  
  • Olgun NS, Patel HJ, Stephani R and Reznik SE.  Evaluation of Acute Toxicity of Novel Selective ETA Receptor Antagonists That Control Preterm Birth in a Mouse Model.  St. John’s University Student Poster Day (2009).
  • Olgun NS, Stephani R, Patel H and Reznik SE. A Series of Novel 1-3-6-Trisubstituted-2-Carboxy-Quinol-4-One Endothelin-A Antagonists. St. John’s University College of Pharmacy Research Day, poster presentation (2009).
  • Olgun NS, Patel HJ, Stephani R and Reznik SE.  Evaluation of Acute Toxicity of Novel Selective ETA Receptor Antagonists That Control Preterm Birth in a Mouse Model. St. John’s University College of Pharmacy Research Day, poster presentation (2009).               
  • Non-traditional Roles For MD’s.  Watson Pre-Health Honor Society Address.  St. John’s University (2009).             
  • From Mice to Microarrays:  Identifying the Key Players in Infection-Associated Preterm Birth. St. John’s University PharmD Freshmen Presentation (2009).             
  • Munnangi S, Madankumar R, Alimchandani M, Varghese A, Gross SJ and Reznik SE. Pregnancy Associated Plasma Protein-A2: A Novel Biomarker For Down Syndrome. St. John’s University Faculty Research Forum, poster presentation (2010).            
  • Olgun NS, Stephani RA, Patel HJ and Reznik SE. Characterization of a Novel Series of Endothelin-A Receptor Antagonists in the Setting of Infection-Associated Preterm Birth. St. John’s University Faculty Research Forum, poster presentation (2010).
  • Munnangi S, Madankumar R, Alimchandani M, Varghese A, Gross SJ and Reznik SE. Pregnancy Associated Plasma Protein-A2: A Novel Biomarker For Down Syndrome. St. John’s University Student Poster Day (2010).
  • Olgun NS, Stephani RA, Patel HJ and Reznik SE. Characterization of a Novel Series of Endothelin-A Receptor Antagonists in the Setting of Infection-Associated Preterm Birth. St. John’s University Student Poster Day (2010).             
  • Olgun NS, Stephani RA, Patel HJ and Reznik SE. Characterization of a Novel Series of Endothelin-A Receptor Antagonists in the Setting of  Infection-Associated Preterm Birth.  St. John’s University College of Pharmacy Research Day, poster presentation (2010).  
  • Pregnancy Associated Plasma Protein-A2: A Novel Biomarker For Down Syndrome. Research Seminar at St. John’s University (2010).
  • Grant Writing:  War Stories and Advice.  St. John’s University Faculty Writing Initiative Event (2011).              
  • Infection Associated Preterm Birth.  St. John’s University Women in Science Presentation (2011).             
  • Abhichandani K, Sundaram S, Munnangi S, Chen C-H, Yen H and Reznik SE. Prolactin Controls Infection-Associated Preterm Birth in a Murine Model.  St. John’s University Faculty Research Forum, poster presentation (2011).
  • Sundaram S, Ashby C, Abhichandani K, Munnangi S and Reznik SE. N, N-Dimethylacetamide Controls Infection-Associated Preterm Birth in a Murine Model. St. John’s University Faculty Research Forum, poster presentation (2011).     
  • Sundaram S, Ashby C, Abhichandani K, Munnangi S and Reznik SE. N, N-Dimethylacetamide Controls Infection-Associated Preterm Birth in a Murine Model. St. John’s University Student Research Day, poster presentation (2011).    
  • Olgun NS, Patel HJ, Vyas V, Stephani RA, Hanna N and Reznik SE.  Endothelin-A Receptor Antagonists Shut Down Preterm Labor in.the Animal Model:  A Look at Altered Gene Expression. St. John’s University Faculty Research Forum, poster presentation (2012).
  • Olgun NS, Patel HJ, Vyas V, Stephani RA, Hanna N and Reznik SE.  Endothelin-A Receptor Antagonists Shut Down Preterm Labor in.the Animal Model:  A Look at Altered Gene Expression. St. John’s University Student Research Day, poster presentation (2012). 
  • Sundaram S, Ashby C, Abhichandani K, Munnangi S, Reznik SE. N,N-Dimethylacetamide (DMA) Prevents Preterm Birth in a Murine Model By Up Regulating Interleukin 10 (IL-10).  St. John’s University Student Research Talk.        
  • Preterm Birth:  Why Placentas are Submitted.  Montefiore Medical Center Pathology Laboratory Week Lecture (2012).           
  • Women’s History Month STEM Panelist.  St. John’s University Women in Science Panel Discussion (2013).
  • Watson Honor Society Address. St. John’s University (2013). 
  • Donepudi R, Mahajan Prathamesh, Einstein F and Reznik SE.  The Role of Endothelin−1 in Endotoxin−Triggered Release of Placental Pro−Inflammatory Cytokines.   St. John’s University Faculty Research Forum, poster presentation (2013).      
  • Donepudi R, Mahajan Prathamesh, Einstein F and Reznik SE. The Role of Endothelin−1 in Endotoxin−Triggered Release of Placental Pro−inflammatory Cytokines (2013).
  • Reznik SE.  Placental Pathology.  Lecture to Montefiore Medical Center/Albert Einstein College of Medicine pathology residents (2013).   
  • St. John’s University Grants Mentoring Program Invited Speaker (2013).
  • Vyas V, Ashby CR, Olgun NS, Sundaram S, Salami O, Munnangi S, Pekson R and Reznik SE.  Inhibition of Sphingosine Kinase Prevents Inflammation-Associated Preterm Birth in a Murine Model by Suppressing Pro-inflammatory Responses.  St. John’s University Faculty Research Forum, poster presentation (2014).
  • Vyas V, Ashby CR, Olgun NS, Sundaram S, Salami O, Munnangi S, Pekson S and Reznik SE.  Inhibition of Sphingosine Kinase Prevents Inflammation-Associated Preterm Birth in a Murine Model by Suppressing Pro-inflammatory Responses.  St. John’s University Student Research Day, poster presentation (2014).
  • Pekson R, Gorasiya S, Poltoratsky V, Vancurova I and Reznik SE. The Anti-inflammatory Action of N,N-Dimethylacetamide. St. John’s University Faculty Research Forum, poster presentation (2015).        
  • Tariq A, Naeem T, Pak S and Reznik SE. The Role of Gabapentin in Neuropathic Pain Management of Spinal Cord Injuries. St. John’s University Student Research Day, poster presentation (2015).
  • St. John’s University AHA Red Dress Gala Guest Speaker (2015).
  • Faculty Research Forum Guest Speaker (2015).
  • The Organ That Determines the Future: Current Concepts in Placental Pathology. Montefiore Medical Center/Albert Einstein College of Medicine, Department of Obstetrics and Gynecology and Women’s Health, Division of Maternal Fetal Medicine Talk (2016).
  • Pekson R, Poltoratsky V, Gorasiya S, Sundaram S, Ashby CR, Vancurova I and Reznik SE. N,N-Dimethylacetamide Regulates Pro-Inflammatory Cytokine Secretion in RAW 264.7 Cells and Human Placental Explants by Inhibition of Nuclear Factor Kappa B. St. John’s University Faculty Research Forum/Student Research Day (2016), poster presentation.
  • Giusto K and Reznik SE. Inhibition of Sphingosine Kinase Prevents Tumor Necrosis Factor Alpha Induced Preterm Birth in a Murine Model. St. John’s University Faculty Research Forum/Student Research Day (2016), poster presentation.
  • Gorasiya S and Reznik SE. The Role of Extracellular Heat Shock Protein (HSP) 70 in the Regulation of Inflammatory Cytokines in Human Placenta and Primary Trophoblasts. St. John’s University Student Research Day (2016), poster presentation.
  • Reznik SE. Graduate Orientation Welcoming Address, Department of Pharmaceutical Sciences, St. John’s University (2016).
  • Manuel C and Reznik SE. Pre-maternal High-fat Diet Consumption Initiates Preterm Birth by Potentiating the Actions of Lipopolysaccharide At Toll-like Receptor 4 and Decreasing Utero-placental Antioxidant Capacity. St. John’s University Research Day (2017), poster presentation, best poster award.
  • Gorasiya S, Mushi J, Yoganathan S and Reznik SE. Anti-Inflammatory Activity of N,N-Diethylacetamide (DEA) and N,N-Dipropylacetamide (DPA) In In Vitro and Ex Vivo Models of Inflammation-Induced Preterm Birth. St. John’s University Research Day (2017), oral presentation.
  • The Placenta: Protector, Provider, Predictor of our Futures. Montefiore Medical Center Pathology Laboratory Week Lecture (2017).
  • Koya J, Shen T, Ashby CR and Reznik SE. N,N-Dimethylacetamide Regulates Pro-inflammatory Cytokine and Chemokine Secretion in Human Intestinal Epithelial Cells and Monocytes by Inhibition of Nuclear Factor Kappa B. St. John’s University Research Day (2018), poster presentation.
  • Giusto K and Reznik SE. Inhibition of Sphingosine Kinase Attenuates the Pro-Inflammatory Response in In-Vivo and In-Vitro Models of Inflammation Induced Preterm Birth. St. John’s University Research Day (2018), poster presentation.
  • Jacob J, Reznik SE, Reidy K, Kohlberg RH, Winkler CA, Kopp J, Davis RL,  Simpson C and Rosenberg A. Does APOL1 Status Correlate with a Distinct  Histopathologic Pattern in the Placenta? Pathology Department Research Retreat,  Montefiore Medical Center/Albert Einstein College  of Medicine, poster  presentation (2018).
  • Novel Approaches to Preventing Preterm Birth. Montefiore Medical  Center/Albert Einstein College of Medicine, Department of Pediatrics, Division of Neonatology Grand Rounds (2018).

REGIONAL PRESENTATIONS:

  • Patki M, Giusto K, Reznik SE and Patel K. Vaginal Delivery of Liquisolid Formulation of Hydroxyprogesterone Caproate and Dimethylacetamide for the Treatment of Preterm Labor. American Association of Pharmaceutical Scientists, Northeastern Division Regional Meeting, oral presentation (2017).
  • Manuel CR and Reznik SE. Endotoxin Tolerance Protects High Fat Diet Mice From Preterm Delivery. New England Science Symposium at Harvard Medical School, poster presentation (2018).
  • De Vera AA, Gupta P, Lei Z, Liao D, Reznik SE and Chen Z-S. Immuno-oncology Agent IPI-549 is a Modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated Multidrug Resistance (MDR) in Cancer Cells. Frontiers in Cancer Immunotherapy, New York Academy of Sciences, poster presentation (2018).
  • Giusto K, Patki M, Patel K and Reznik SE. A Vaginal Nanoformulation of SKII Rescues Mice From Lipopolysaccharide Induced Preterm Birth With No Major Teratogenic Effects. Dr. Charles I. Jarowski Industrial Pharmacy Symposium, poster and platform presentations (2018).
  • Koya J, Shen T, Ashby CR and Reznik SE. N,N-Dimethylacetamide Regulates Pro-inflammatory Cytokine and Chemokine Secretion in Human Intestinal Epithelial Cells and Monocytes by Inhibition of Nuclear Factor Kappa B. Dr. Charles I. Jarowski Industrial Pharmacy Symposium, poster presentation (2018).
  • De Vera AA, Gupta P, Lei Z, Liao D, Reznik SE and Chen Z-S. Immuno-oncology Agent IPI-549 is a Modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated Multidrug Resistance (MDR) in Cancer Cells. Dr. Charles I. Jarowski Industrial Pharmacy Symposium, poster presentation (2018).
  • Acosta-Martinez M, Yang L, Manuel CR and Reznik SE. Palmitic Acid Induces the Secretion of Placental Exosome-like Vesicles Containing Pro-inflammatory miRNAs. Extracellular Vesicles in Diagnostics and Therapeutics Conference, New York Academy of Sciences, poster presentation (2019).

NATIONAL PRESENTATIONS:

  • Patel HJ, Reznik SE, Lengyel I and Stephani R.  Design, Synthesis and Structural Activity Relationship of 1,3,6-Trisubstituted-4-oxo-1,4,-dihydroquinoline-2-carboxylic Acid as Selective ET-A Antagonists for Prevention of Preterm Labor (PTL).  American Chemical Society, poster presentation (2009).
  • Madankumar R, Munnangi S, Chen, C-H, Yen H, Wang W and Reznik SE. Differential Expression of Placental Genes in a Mouse Model of Infection-Associated Preterm Labor.  American College of Medical Genetics, poster presentation (2009).
  • Olgun NS, Patel HJ, Stephani R and Reznik SE.  Evaluation of Acute Toxicity of Novel Selective ETA Receptor Antagonists That Control Preterm Birth in a Mouse Model. Mid-Atlantic Society of Toxicology, poster presentation (2009).
  • Olgun NS, Arita Y, Gurzenda EM, Koo H-C, Peltier MR, Reznik SE and Hanna N.  Placental Infection Induces Endothelin-1 Expression in Mid-Trimester Placental Explants.  American Society of Reproductive Immunology, poster presentation (2013).            
  • Smith C, Maidhof W, Reznik SE, Conry J, Kruger D, Beysolow S, Wu W,  Murphy C and Etzel J.  An Educational Model to Expand Interprofessional  Education and Practice. Association of Schools of Allied Health Professions,  poster presentation (2013).
  • Mahajan P, Donepudi R, Einstein F and Reznik SE.  The Role of Endothelin-1 in Endotoxin-Triggered Release of Placental Pro-inflammatory Cytokines.  American Society of Reproductive Immunology, poster presentation (2014). 
  • Sundaram S, Ashby CR and Reznik SE.  N,N-Dimethylacetamide Controls Infection-Associated Preterm Birth in a Murine Model. American Society of Reproductive Immunology, poster presentation (2014).
  • Mahajan P, Donepudi R, Einstein F and Reznik SE.  The Role of Endothelin-1 in Endotoxin-Triggered Release of Placental Pro-inflammatory Cytokines.  Graduate Research Association of Students in Pharmacy, poster presentation (2014).
  • Sundaram S, Ashby CR and Reznik SE.  N,N-Dimethylacetamide Controls Infection-Associated Preterm Birth in a Murine Model.  Graduate Research Association of Students on Pharmacy, poster presentation (2014).
  • Hjorten RC, Rosenblum S, Myrie J, Ruiz BL, Suzuki M, Reznik SE, Winkler CA, Kopp JB, Kaskel FJ and Reidy KJ. Mother and Baby Apol1 High Risk Alleles in Births Complicated by Preeclampsia. American Society of Nephrology, poster presentation (2016).
  • Reidy K, Hjorten R, Simpson C, Rosenberg A, Rosenblum SD, Kovesdy C, Tylavsky F, Myrie J Ruiz B, Mozhui K, Haque S, Suzuki M, Reznik SE, Kaskel F, Kopp JB, Winkler CA and Davis RL. Fetal but not Maternal APOL1 Genotype is Associated with Increased Risk for Preeclampsia among African-Americans. American Association of Nephrology, poster presentation (2017).
  • Patki M, Gorasiya S, Giusto K, Reznik SE and Patel K. Hydroxyprogesterone and Dimethylacetamide Co-loaded Self Nanoemulsifying Vaginal Tablet for the Treatment of Preterm Labor. American Association of Pharmaceutical Scientists, poster presentation (2018).
  • Patki M, Giusto K, Reznik SE and Patel K. Vaginal Nanoformulation of 17-Alpha-hydroxyprogesterone Prevents LPS-Induced Preterm Birth in Mice. Graduate Research Association of Students on Pharmacy, poster presentation, first place prize (2018).
  • Acosta-Martinez R, Yang L, Manuel CR and Reznik SE. Palmitic Acid Induces the Secretion of Placental Exosome-like Vesicles Containing Pro-inflammatory the Secretion of Placental Exosome-like Vesicles Containing Pro-inflammatory miRNAs. American Society for Cell Biology, poster presentation (2018).
  • Patki M, Giusto K, Ashby CR, Munnangi S, Patel K and Reznik SE. Vaginal Nano-formulation of a Sphingosine Kinase Inhibitor: A Novel Therapeutic Intervention for the Prevention of Preterm Labor. Scientista Symposium, poster presentation (2019), poster presentation.

INTERNATIONAL PRESENTATIONS:

  • Olgun NS, Patel HJ, Stephani R and Reznik SE.  Evaluation of Acute Toxicity of Novel Selective ETA Receptor Antagonists That Control Preterm Birth in a Mouse Model.  Society of Toxicology, poster presentation (2009).
  • Olgun NS, Stephani R, Patel H and Reznik SE. A Series of Novel 1-3-6-Trisubstituted-2-Carboxy-Quinol-4-One Endothelin-A Antagonists. Eleventh International Conference of Endothelin (ET-11), poster presentation (2009). 
  • Olgun NS, Stephani RA, Patel HJ and Reznik SE. Characterization of a Novel Series of Endothelin-A Receptor Antagonists in the Setting of Infection-Associated Preterm Birth. Society of Toxicology, poster presentation (2010).
  • Abhichandani K, Sundaram S, Munnangi S, Chen C-H, Yen H and Reznik SE.  Prolactin Controls Infection-Associated Preterm Birth in a Murine Model.  Society of Gynecologic Investigation, short talk (2011).
  • Olgun NS, Stephani RA, Patel HJ and Reznik SE. Characterization of a Novel Series of Endothelin-A Receptor Antagonists in the Setting of Infection-Associated Preterm Birth. Society of Toxicology, poster presentation (2011). 
  • Dai M, Shikani HJ, Stephani RA, Reznik SE, Tanowitz HB, Weiss LM, Desruisseaux MS.  A Novel Endothelin Receptor Antagonist Increases Rates of Cerebral Malaria Survival, Twelfth International Conference of Endothelin (ET-12), short talk (2012).
  • Olgun NS, Patel HJ, Vyas V, Stephani RA, Hanna N and Reznik SE. Endothelin-A Receptor Antagonists Shut Down Preterm Labor in.the Animal Model:  A Look at Altered Gene Expression. Society of Toxicology, poster presentation (2012).
  • Sundaram S, Ashby C, Abhichandani K, Munnangi S and Reznik SE.  N,N Dimethylacetamide (DMA) Prevents Preterm Birth in a Murine Model By Up Regulating Interleukin 10 (IL-10).  Society of Gynecologic Investigation, short talk (2012).
  • Abhichandani K, Shah N, Sundaram S, Munnangi S, Chen C-H, Yen H and Reznik SE.  Prolactin Controls Infection-Associated Preterm Birth in a Murine Model.  Society of Gynecologic Investigation Summit Meeting, poster presentation (2012).
  • Sundaram S, Ashby CR, Sampat V, Sitapara R, Mantell L, Abhichandani K, Munnangi S and Reznik SE.  N,N Dimethylacetamide Prevents Infection-Associated Preterm Birth. Society of Gynecologic Investigation Summit Meeting, short talk (2012).
  • Donepudi R, Mahajan P, Einstein F and Reznik SE.  The Role of Endothelin−1 in Endotoxin−Triggered Release of Placental Pro−Inflammatory Cytokines.  Society for Gynecologic Investigation Meeting, poster presentation (2013).
  • Suzuki M, Heo H, Gebb JS, Reznik SE, Einstein MH, Einstein F and Greally JM. Epigenomic Dysregulation in Pre-eclampsia.  Translational Science Meeting, poster presentation (2013).
  • Abhichandani K, Shah N, Sundaram S, Munnangi S, Chen C-H, Yen H and Reznik SE. Prolactin Controls Infection-Associated Preterm Birth in a Murine Model.  Society of Gynecologic Investigation Summit Meeting, one of top ten oral presentations (2013).
  • Mahajan P, Donepudi R, Einstein F and Reznik SE.  The Role of Endothelin−1 in Endotoxin−Triggered Release of Placental Pro−Inflammatory Cytokines.  Society of Toxicology Meeting, poster presentation (2014).
  • Lulla A, Reznik SE, Trombetta L and Billack B.  A New Purpose for Ebselen as a Prophylactic to Chemical Threats?  Society of Toxicology Meeting, poster presentation (2014).
  • Sparavalo O, Tumu HCR, Giusto K, Nicholson S, Guralnik M, de Lira Nogueira L, Reznik S, Trombetta L and Billack B.  Mechlorethamine Dermatotoxicity is Potentiated by the Absence of Nrf2 in the Mouse Ear Vesicant Model.  Society of Toxicology Meeting, poster presentation (2014).
  • Suzuki M, Hye HJ, Patterson N, Reznik SE, Einstein MH, Einstein FH and Greally JM. Exploratory Analysis of Distinct Placental DNA Methylation and Transcription Alterations in Pre-eclampsia Patients.  Translational Science Meeting, poster presentation (2014).
  • Pekson R, Poltoratsky V, Gorasiya S, Sundaram S, Ashby CR, Vancurova I and Reznik SE. N,N-Dimethylacetamide Regulates Pro-Inflammatory Cytokine Secretion in RAW 264.7 Cells and Human Placental Explants by Inhibition of Nuclear Factor Kappa B. Society for Reproductive Investigation  Meeting, poster presentation (2016).
  • Giusto K and Reznik SE. Inhibition of Sphingosine Kinase Prevents Tumor Necrosis Factor Alpha Induced Preterm Birth in a Murine Model. Society for Reproductive Investigation Meeting, poster presentation (2016).
  • Manuel C and Reznik SE. Pre-maternal High-fat Diet Consumption Initiates Preterm Birth by Potentiating the Actions of Lipopolysaccharide At Toll-like Receptor 4 and Decreasing Utero-placental Antioxidant Capacity. Society for Reproductive Investigation, poster presentation (2017).
  • Gorasiya S, Mushi J, Yoganathan S and Reznik SE. Anti-Inflammatory Activity of N,N-Diethylacetamide (DEA) and N,N-Dipropylacetamide (DPA) In In Vitro and Ex Vivo Models of Inflammation-Induced Preterm Birth. Society for Reproductive Investigation, poster presentation (2017).
  • Hjorten R, Rosenblum S, Myrie J, Haque S, Ruiz B, Suzuki M, Reznik SE, Winkler C, Kopp J and Reidy K. Possible Role for Maternal and Fetal APOL1 High Risk Alleles in Births Complicated by Preeclampsia. Pediatric Academic Societies Conference, poster presentation (2017).
  • Manuel C and Reznik SE. Resolving the Mechanisms of High-Fat Diet Induced Preterm Birth: Is Immune Tolerance a Better Line of Defense than Immune Inhibition? Keystone Symposium--Maternal Fetal Crosstalk: Harmony vs. Conflict, poster presentation (2017).
  • Giusto K and Reznik SE. Inhibition of Sphingosine Kinase Attenuates the Pro-Inflammatory Response in In-Vivo and In-Vitro Models of Inflammation Induced Preterm Birth. Keystone Symposium--Maternal Fetal Crosstalk: Harmony vs. Conflict, poster presentation (2017).
  • Koya J, Shen T, Ashby CR and Reznik SE. N,N-Dimethylacetamide Regulates Pro-inflammatory Cytokine and Chemokine Secretion in Human Intestinal Epithelial Cells and Monocytes by Inhibition of Nuclear Factor Kappa B. Cancer Pharmacology Research Synergy Conference, poster presentation (2017).
  • De Vera A, Pranav G, Reznik SE and Chen Z-S. IPI-549 Is a Modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated Multi-drug Resistance (MDR) in Cancer Cells. Cancer Pharmacology Research Synergy Conference, poster presentation (2017).
  • Jacob J, Reznik SE, Reidy K, Kohlberg RK and Rosenberg A. Does APOL1 Status Correlate with a Distinct Histopathologic Pattern in the Placenta? United States and Canadian Academy of Pathology, poster presentation (2018).
  • Manuel CR and Reznik SE. Administration of Subclinical Doses of Lipopolysaccharide Simultaneously Reverses Dysbiosis and Protects High Fat Diet Mice From Preterm Delivery. Society for Reproductive Investigation, poster presentation (2018).
  • Giusto K and Reznik SE. Inhibition of Sphingosine Kinase Attenuates the Pro-Inflammatory Response in In-Vivo and In-Vitro Models of Inflammation Induced Preterm Birth. Society for Reproductive Investigation, poster presentation (2018).
  • Manuel CR and Reznik SE. Immune Tolerance Attenuates High Fat Diet Potentiated Preterm Birth. Society for Reproductive Investigation (Late Breaking Abstract), poster presentation (2018).
  • Giusto K, Patki M, Patel K and Reznik SE. A Vaginal Nanoformulation of SKII, a Sphingosine Kinase Inhibitor, Rescues Mice From Lipopolysaccharide Induced Preterm Birth. Society for Reproductive Investigation (Late Breaking Abstract), poster presentation (2018).
  • Manuel CR and Reznik SE. Immune Tolerance Attenuates High Fat Diet Potentiated Preterm Birth. Symposium on Harnessing Immune Metabolism, poster presentation (2018).

BIBLIOGRAPHY

EXPERIMENTAL PAPERS:

  • Wang W, Yen H, Chen C-H, Jasani N, Soni R, Koscica K and Reznik SE. Endothelin-1 and Matrix Metalloproteinase-1 Function in the Same Molecular Pathway in Infection-Associated Preterm Birth, Molec Med 16:  505-512 (2010).
  • Olgun NS, Stephani RA, Patel HJ and Reznik SE. Blockade of Endothelin-1 With a Novel Series of 1,3,6-Trisubstituted-2-carboxy-quinol-4-one’s Controls Infection-Associated Preterm Birth, Am J Path 177:  1929-1935 (2010).
  • Dai M, Reznik SE, Spray DC, Weiss LM, Tanowitz HB, Gulinello M and Desruisseaux MS. Persistent Cognitive and Motor Deficits After Successful Antimalarial Treatment in Murine Cerebral Malaria, Microbes Infect 12:  1198-1207 (2010).
  • Patel HJ, Olgun NS, Lengyel I, Reznik SE and Stephani RA. Synthesis and Pharmacological Activity of 1,3,6-Trisubstituted-4-Oxo-1,4-Dihydroquinoline-2-Carboxylic Acids as Selective ETA Antagonists, Bioorg Med Chem Lett 20:  6840-6844 (2010).
  • Ouhilal S, Vuguin P, Cui L, Du X-Q, Gelling RW, Reznik SE, Russell R, Parlow AF, Karpovsky C, Santoro N and Charron MJ.  Hypoglycemia, Hyperglucagonemia and Feto-placental Defects in Glucagon Receptor Knockout Mice: A Role for Glucagon Action in Pregnancy Maintenance, Am J Phys Endo Metab 302:  E522-E531 (2012).
  • Dai M, Freeman B, Shikani HJ, Bruno FP, Weiss LM, Tanowitz HB, Spray DC,Macias R, Reznik SE, and Desruisseaux MS.  Altered Regulation of Akt Signaling with Murine Cerebral Malaria, Effects on Long-term Neuro-cognitive Function, Restoration with Lithium Treatment. PLoS One 7:  e44117 (2012).
  • Dai M, Shikani HJ, Freeman B, Bruno FP, Tanowitz HB, Weiss LM, Reznik SE, Stephani RA, and Desruisseaux MS.  A Novel Endothelin Receptor Antagonist Prevents Cerebral Microvascular Hemorrhage When Used in Conjunction with an Anti-malarial Agent in Plasmodium berghei ANKA-infected Mice. Life Sci 91:  687-692 (2012).           
  • Sundaram S, Ashby CR, Pekson R, Sampat V, Sitapara R, Mantell L, Chen C-H, Yen H, Abhichandani K, Munnangi S, Khadtare N, Stephani RA and Reznik SE. N, N-Dimethylacetamide Regulates the Pro-inflammatory Response Associated with Endotoxin and Prevents Preterm Birth.  Am J Path 183:  422-430 (2013).
  • Lulla A, Reznik SE, Trombetta L and Billack B.  Use of the Mouse Ear Vesicant Model to Evaluate the Effectiveness of Ebselen as a Countermeasure to the Nitrogen Mustard Mechlorethamine.  J App Tox 34: 1373-1378 (2014).
  • Munnangi S, Gross SJ, Madankumar R and Reznik SE.  Pregnancy Associated Plasma Protein-A2:  A Novel Biomarker for Down Syndrome.  Placenta 35: 900-906 (2014).
  • Adler E, Madankumar R, Rosner M and Reznik SE.  Increased Placental Trophoblast Inclusions in Placenta Accreta. Placenta 35: 7035-7038 (2014).
  • Olgun NS, Hanna N and Reznik SE.  BQ-123 Prevents LPS-Induced Preterm Birth Via the Induction of Uterine and Placental IL-10. Tox App Pharm 282: 275-284 (2015).
  • Vyas V, Ashby CR, Olgun NS, Sundaram S, Salami O, Munnangi S, Pekson R, Mahajan P and Reznik SE. Inhibition of Sphingosine Kinase Prevents Lipopolysacccharide Induced Preterm Birth and Suppresses Pro-inflammatory Responses in a Murine Model. Am J Path 185: 862-869 (2015).
  • Suzuki M, Maekawa R, Patterson ME, Reynolds DM, Calder BR, Reznik SE, Heo HJ, Einstein FH and Greally JM. Amnion as a Surrogate Tissue Reporter of the Effects of Preeclampsia on the Fetus. Clin Epigen 8:67 (2016).
  • Pekson R, Poltoratsky V, Gorasiya S, Sundaram S, Ashby CR, Vancurova I and Reznik SE. N,N-Dimethylacetamide Significantly Attenuates LPS- and TNFα-Induced Proinflammatory Responses Via Inhibition of the Nuclear Factor Kappa B Pathway. Molec Med 22: 747-758 (2016).
  • Manuel CR, Charron M, Ashby CR and Reznik SE. Saturated and Unsaturated  Fatty Acids Differentially Regulate In Vitro and Ex Vivo Placental Anti-Oxidant  Capacity. Am J Reprod Immunol, 80:e12868 (2018)  https://doi.org/10.1111/aji.12868. (Featured on journal cover.)
  • Reidy KJ, Hjorten RC, Simpson CL, Rosenberg AZ, Rosenblum SD, Kovesdy CP, Tylavsky FA, Myrie J, Ruiz BL, Mozhui K, Haque S, Suzuki M, Jacob J, Reznik SE, Kaskel FJ, Kopp JB, Winkler CA and Davis RL. Fetal Not Maternal apol1 Genotype Associated with Risk for Preeclampsia. Am J Hum Gen 103: 367-376 (2018).
  • De Vera AA, Gupta P, Lei Z, Liao D, Narayanan S, Teng Q, Chen Z-S and Reznik SE. Immuno-oncology agent IPI-549 Is a Modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-Mediated Multi-drug Resistance (MDR) in Cancer: In Vitro and In vivo. Cancer Lett, 442: 91-103 (2019).
  • Manuel CR, Latuga MS, Ashby CR and Reznik SE. Immune Tolerance Attenuates Gut Dysbiosis, Dysregulated Uterine Gene Expression and High-Fat Diet Potentiated Preterm Birth in Mice. Am J Obstet Gynecol, 596.e1-596.e28 (2019).
  • Patki M, Giusto K, Gorasiya S, Patel K and Reznik SE. 17-Alpha-hydroxyprogesterone Nanoemulsifying Preconcentrate Loaded Vaginal Tablet: A Novel Non-invasive Approach for the Prevention of Preterm Birth. Pharmaceutics, accepted pending revisions.

JOURNAL ISSUES EDITED

  • Reznik SE. Editor, Novel Pharmacotherapeutic Targets and Emerging Approaches to Preterm Birth, Part 1, Special Hot Topic Issue of Curr Pharm Des 23 (40) (2017).
  • Reznik SE. Editor, Novel Pharmacotherapeutic Targets and Emerging Approaches to Preterm Birth, Part 2, Special Hot Topic Issue of Curr Pharm Des  24 (9) (2018).

REVIEW ARTICLES, BOOK CHAPTERS AND CONTRIBUTIONS TO TEXTBOOKS: 

  • Reznik SE. “Plan B:” How It Works. Science Shows It Is Not An Abortifacient. Health Prog 91:  59-61 (2010).
  • Olgun NS and Reznik SE.  The Matrix Metalloproteases and Endothelin-1 in Preterm Birth. Obstet Gynecol Internat 2010: 657039.
  • Vyas V, Ashby CR and Reznik SE.  Sphingosine Kinase: A Novel Putative Target for the Prevention of Infection-Triggered Preterm Birth.  Obstet Gynecol Internat 2013:302592.
  • Sahasrabudhe N, Mobasseri M, Reznik SE and Williams Z. Chronic Endometritis and Recurrent Pregnancy Loss. Curr Obstet Gynecol Rep 6: 55-61 (2017). 
  • Manuel CR, Ashby CR and Reznik SE. Discrepancies in Animal Models of Preterm Birth, Curr Pharm Des 23: 6142-6148 (2017).
  • Gorasiya S, Mushi J, Giusto K, Pekson R, Yoganathan S and Reznik SE.  Repurposing N,N-Dimethylacetamide (DMA), a Pharmaceutical Excipient, as a  Prototype Novel Anti-inflammatory Agent for the Prevention and/or Treatment of  Preterm Birth. Curr Pharm Des 24: 989-992 (2018).
  • De Vera AA and Reznik SE. Combining PI3K/Akt/mTOR Inhibition with  Chemotherapy. In Tyrosine Kinase Inhibitors as Sensitizing Agents for  Chemotherapy, part of the series: Cancer Sensitizing Agents for Chemotherapy  (2018).
  • Teng Q-X, Ashar YV, Gupta P, Reznik SE, Wurpel JND and Chen Z-S. Revisiting mTOR Inhibitors as Anti-cancer Agents. Drug Disc Today, in press.
  • Kuan K and Reznik SE. Intrauterine Fetal Demise and Intestinal Atresia: An Autopsy Investigation. Academic Pathology, submitted.

CASE REPORTS:

  • Patel M, Beckerman KP, Reznik S, Madan RP and Goldman D. Vertical Transmission of Cryptococcus neoformans to an HIV-exposed Premature Neonate, J Perinatol 32:  235-237 (2012).

LETTERS AND EDITORIALS:

  • Reznik SE.  Letter to the Editor Responding to Commentary Criticizing Health Progress Article.  Ethics and Medics (2010). 
  • Reznik SE, Gardner E and Ashby CR. Cannabidiol: A Potential Treatment for Post Ebola Syndrome? Int J Inf Dis, 52:74-76 (2016).
  • Reznik SE and Ashyby CR. Sofosbuvir: An Anti-Viral Drug with Potential Efficacy Against Zika Infection. Int J Inf Dis, 55: 29-30 (2017).
  • Reznik SE. Editorial: Novel Pharmacotherapeutic Targets and Emerging Approaches to Preterm Birth, Part 1. Curr Pharm Des, 23: 6097 (2017).
  • Reznik SE. Editorial: Novel Pharmacotherapeutic Targets and Emerging Approaches to Preterm Birth, Part 2. Curr Pharm Des, 24: 959 (2018)
  • Reznik SE, Tiwari AK and Ashby CR. Sofosbuvir: A Potential Treatment for Ebola. Front Pharm, 9: 1139 (2018).

 

Dr. Reznik is a nationally recognized expert in perinatal and placental pathology and frequently called upon to serve as an expert witness in medical malpractice cases.