Laura Schramm

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Program Director, Environmental Studies Undergraduate and Graduate ProgramsProfessor
Biological Sciences
St. John's College of Liberal Arts and Sciences
Howard Hughes Medical Associate, Cold Spring Harbor Laboratory, Cold Spring Harbor, NYPhD, SUNY at Stony Brook, Molecular and Cellular PharmacologyMS, St. John’s University, ToxicologyBS, SUNY at Stony Brook, Biochemistry

Areas of Specialization
RNA polymerase III transcription, cancer biology, phytochemicals, chemoprevention, and bioinformatics.

Research
My research focuses on the deregulation of RNA polymerase III transcription in human diseases. My lab has characterized roles for BRF2, BDP1, and MAF1 in various human cancers using computational approaches.

Professional Experience
Professor, Department of Biological Sciences, St. John’s University

Associate Dean

Associate professor, Department of Biological Sciences, St. John’s University

Assistant Professor, Department of Biological Sciences, St. John’s University

Research Scientist/Asst. Professor Radiation/Oncology Department of Radiation/Oncology, The Long Island Campus for the Albert Einstein College of Medicine (LIJMC), Long Island Jewish Medical Center, New Hyde Park

Honors and Awards
2003-2008 - Clare Boothe Luce Assistant Professor, Department of Biological Sciences, St. John’s University, Queens, NY

Cabarcas-Petroski, S.; Olshefsky, G.; Schramm, L. MAF1 is a predictive biomarker in HER2-positive breast cancer. PLoS One 2023, 18, e0291549, doi:10.1371/journal.pone.0291549.

Schramm, L. Comment on Li et al. BDP1 Variants I1264M and V1347M Significantly Associated with Clinical Outcomes of Pediatric Neuroblastoma Patients Imply a New Prognostic Biomarker: A 121-Patient Cancer Genome Study. Diagnostics 2021, 11, 2364. Diagnostics 2022, 12, doi:10.3390/diagnostics12030608.

Hinić, S.; Rich, A.; Anayannis, N.V.; Cabarcas-Petroski, S.; Schramm, L.; Meneses, P.I. Gene Expression and DNA Methylation in Human Papillomavirus Positive and Negative Head and Neck Squamous Cell Carcinomas. Int J Mol Sci 2022, 23, doi:10.3390/ijms231810967.

Cabarcas-Petroski, S.; Schramm, L. BDP1 Expression Correlates with Clinical Outcomes in Activated B-Cell Diffuse Large B-Cell Lymphoma. BioMedInformatics 2022, 2, doi:10.3390/biomedinformatics2010011.

Cabarcas-Petroski, S.; Olshefsky, G.; Schramm, L. BDP1 as a biomarker in serous ovarian cancer. Cancer Med 2022, doi:10.1002/cam4.5388.

Cabarcas-Petroski, S.; Schramm, L. BDP1 Alterations Correlate with Clinical Outcomes in Breast Cancer. Cancers (Basel) 2022, 14, doi:10.3390/cancers14071658.

Cabarcas-Petroski, S.; Meneses, P.I.; Schramm, L. A meta-analysis of BRF2 as a prognostic biomarker in invasive breast carcinoma. BMC Cancer 2020, 20, 1093, doi:10.1186/s12885-020-07569-8.

Diette, N.; Koo, J.; Cabarcas-Petroski, S.; Schramm, L. Gender Specific Differences in RNA Polymerase III Transcription. J Carcinog Mutagen 2016, 7, doi:10.4172/2157-2518.1000251.

Koo, J., S. Cabarcas-Petroski, J.L. Petrie, N. Diette, R.J. White, and L. Schramm, Induction of proto-oncogene BRF2 in breast cancer cells by the dietary soybean isoflavone daidzein. BMC Cancer, 2015. 15(1): p. 905.

Nole, N., J. Koo, and L. Schramm, Sex Differences in TFIIIB expression in C57BL/6 Mice Treated with EGCG. In Vitro Cellular & Developmental Biology-Animal, 2015. 51: p. S42-S42.

Koo, J. and L. Schramm, Soy, Have we Analyzed all the Risks? Journal of carcinogenesis & mutagenesis, 2015. 6.

Koo, J., N. Nole, and L. Schramm, Regulation of TFIIIB Activity in Estrogen Receptor Positive Breast Cancer Cells by Daidzein. In Vitro Cellular & Developmental Biology-Animal, 2015. 51: p. S28-S29.

Nole, N., J. Koo, J. Jacob, and L. Schramm, Differential Regulation of RNA Polymerase III Transcription by EGCG. In Vitro Cellular & Developmental Biology-Animal, 2014. 50: p. S27-S28.

Koo, J. and L. Schramm, BRF2, a Biomarker in Cancer? Journal of carcinogenesis & mutagenesis, 2014. 6(205).

Schramm, L., Going Green: The Role of the Green Tea Component EGCG in Chemoprevention. Journal of carcinogenesis & mutagenesis. 2013;4(142):1000142.

Cabarcas, S. and L. Schramm, RNA polymerase III transcription in cancer: the BRF2 connection. Molecular Cancer, 2011. 10.

Veras, L., E.M. Rosen, and L. Schramm, Inhibition of RNA Polymerase III Transcription by BRCA1. Journal of Molecular Biology, 2009. 387(3): p. 523-531.

Cabarcas, S.M. and L. Schramm, Inhibition of gene external RNA polymerase III transcription by PTEN. Faseb Journal, 2009. 23.

Cabarcas, S., J. Jacob, I. Veras, and L. Schramm, Differential expression of the TFIIIB subunits Brf1 and Brf2 in cancer cells. Bmc Molecular Biology, 2008. 9.

Aneja, K.K., P. Guha, R.Y. Shilpi, S. Chakraborty, L.M. Schramm, and D. Haldar, The presence of distal and proximal promoters for rat mitochondrial glycerol-3-phosphate acyltransferase. Archives of Biochemistry and Biophysics, 2008. 470(1): p. 35-43.

Rollins, J., I. Veras, S. Cabarcas, I. Willis, and L. Schramm, Human Maf1 negatively regulates RNA polymerase III transcription via the TFIIB family members Brf1 and Brf2.International Journal of Biological Sciences, 2007. 3(5): p. 292-302.

Jacob, J., S. Cabarcas, I. Veras, N. Zaveri, and L. Schramm, The green tea component EGCG inhibits RNA polymerase III transcription. Biochemical and Biophysical Research Communications, 2007. 360(4): p. 778-783.

Aneja, K.K., S. Chakraborty, L. Schramm, and D. Haldar, Distinguishing Properties of mitochondrial glycerol-3-phosphate acyltransferase distal and proximal promoter.Faseb Journal, 2006. 20(4): p. A88-A88.

Saxena, A., B.C. Ma, L. Schramm, and N. Hernandez, Structure-function analysis of the human TFIIB-related factor II protein reveals an essential role for the C-terminal domain in RNA polymerase III transcription. Molecular and Cellular Biology, 2005. 25(21): p. 9406-9418.

Zhao, X.M., L. Schramm, N. Hernandez, and W. Herr, A shared surface of TBP directs RNA polymerase II and III transcription via association with different TFIIB family members. Molecular Cell, 2003. 11(1): p. 151-161.

Schramm, L. and N. Hernandez, Recruitment of RNA polymerase III to its target promoters. Genes & Development, 2002. 16(20): p. 2593-2620.

Johnston, I.M., S.J. Allison, J.P. Morton, L. Schramm, P.H. Scott, and R.J. White, CK2 forms a stable complex with TFIII3 and activates RNA polymerase III transcription in human cells. Molecular and Cellular Biology, 2002. 22(11): p. 3757-3768.

Schramm, L., P.S. Pendergrast, Y.L. Sun, and N. Hernandez, Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters. Genes & Development, 2000. 14(20): p. 2650-2663.

Verschuuren, J.J., J. Dalmau, R. Tunkel, B. Lang, F. Graus, L. Schramm, J.B. Posner, J. Newsom-Davis, and M.R. Rosenfeld, Antibodies against the calcium channel beta-subunit in Lambert-Eaton myasthenic syndrome. Neurology, 1998. 50(2): p. 475-479.

Rosenfeld, M.R., N. Malats, L. Schramm, F. Graus, F. Cardenal, N. Vinolas, R. Rosell, M. Tora, F.X. Real, J.B. Posner, and J. Dalmau, Serum anti-p53 antibodies and prognosis of patients with small-cell lung cancer. Journal of the National Cancer Institute, 1997. 89(5): p. 381-385.

Rosenfeld, M.R., I. Bergman, L. Schramm, J.A. Griffin, M.G. Kaplitt, and P.I. Meneses, Adeno-associated viral vector gene transfer into leptomeningeal xenografts. Journal of Neuro-Oncology, 1997. 34(2): p. 139-144.

Rosenfeld, M.R., L. Schramm, J. Dalmau, and M.G. Malkin, Prevalence of serum antibodies against the p53 tumor suppressor gene protein in patients with primary brain tumors. Neurology, 1996. 46(2): p. 5079-5079.

Undergraduate
CHE 3420 Environmental Chemistry, Undergraduate
CHE 200 Environmental Chemistry Graduate
BIO 249 Communication Skills in the Life Sciences, Graduate