Jiyun Kim, M.D., Ph.D.

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Associate Professor
Biological Sciences
St. John's College of Liberal Arts and Sciences
M.D., SUNY at Stony Brook School of MedicinePh.D., SUNY at Stony Brook School of Medicine

Dr. Kim has training in Medicine and in Research.  Before coming to Saint John’s University, her research was in intravital imaging of immune cells in the central nervous system (CNS) using two photon microscopy.  At Saint John’s University, she is a dedicated teacher of Biology and engages in academic and career-advising to pre-healthcare career track undergraduate students.  Her current interest is in experimenting enhanced pedagogy and applying new educational technology platforms to promote diversity, equity and inclusion.

  • Bio3000, Bio3001L
  • Bio3100
  • Bio3300, Bio3301L
  • Bio2250

For Imaging, my main contribution has been examining the immune system dynamics in the central nervous system using intravital multiphoton intravital imaging of mouse models of disease.  Previous works include participation in collaborative landmark finding that ramified microglia are highly dynamic cells at baseline and in response to injury as visualized using CX3CR1gfp/+ mice  (Davalos, et al., 2005; Kim & Dustin, 2006).

Davalos, D., Grutzendler, J., Yang, G., Kim, J.V., Zuo, Y., Jung, S., Littman, D.R., Dustin, M.L., Gan, W.-B. ATP mediates rapid microglial response to local brain injury in vivo. Nature Neurosci. 2005; 8:752-8
http://www.nature.com/neuro/journal/v8/n6/abs/nn1472.html

Kim, J.V., Dustin, M.L. 2006. Innate response to focal necrotic injury inside the blood brain barrier. J. Immunol. 2006; 177:5269-5277
http://www.jimmunol.org/cgi/content/full/177/8/5269

Intravital imaging I performed lead to a remarkable finding that extravasation of neutrophils and monocytes into CNS, induce a fatal viral meningitis in the mouse (Kim, Kang et al., 2009).  I also examined the quality and functional consequences of immunological synapse interactions during viral meningitis (Kang et al., 2011).   

Kim, J.V., Kang, S.S., Dustin, M.L., McGavern, D.B. Myelomonocytic recruitment causes fatal CNS vascular injury in acute viral meningitis. Nature 2008 online Nov 16.doi: 10.1038. Nature 2009; 457: 191-5 http://www.nature.com/nature/journal/v457/n7226/full/nature07591.html

Kang, S.S., Herz, J., Kim, J.V., Debashis Nayak, Phillip Stewart-Hutchinson, Dustin, M.L., McGavern, D.B. Migration of cytotoxic lymphocytes in cell cycle permits local MHC-I-dependent control of division at sites of viral infection.  J. Exp. Med., 2011 vol 208(4): 747-759. http://jem.rupress.org/content/208/4/747.long

For Intravital Imaging, I contributed to developing an intact intravital window surgery to image the mouse spinal cord and its covering tissue through intervertebral window between lumbar spines (Kim et al., 2010):

Kim, J.V., Jiang, N., Tadokoro, C.E., Liu, L., Ransohoff, R.M., Lafaille, J.J., Dustin, M.L. CXCR6 is required for T cell recruitment into injured gray matter in the context of experimental autoimmune encephalomyelitis. J. Immunol. Methods, 2010 Jan 31;352(1-2):89-100.  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808463/?tool=pubmed

During various Transplant Immunology collaborations, immune cell behavior patterns in transplanted kidney and liver injury were examined by intravital imaging:

Walch J.M., Zeng Q., Li Q., Oberbarnscheidt M.H., Hoffman R.A., Williams A.L., Rothstein D.M., Shlomchik W.D., Kim J.V., Camirand G., Lakkis F.G. Cognate antigen directs CD8+ T cell migration to vascularized transplants. J Clin Invest. 2013 Jun 3;123(6):2663-71. doi: 10.1172/JCI66722. Epub 2013 May 15. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668847/ 

Huang, H., Tohmer, S., Al-khafaji, A., Tai, S., Loughran, P., Chen, L., Wang, S., Kim, J.V., Billiar, T.R., Wang, Y., Tsung, A.  DAMPs-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury. Hepatology. 2015 Apr 8. doi: 10.1002/hep.27841. http://onlinelibrary.wiley.com/wol1/doi/10.1002/hep.27841/abstract

 

October 2017: Faculty technology Forum- exhibit
Title: Integrating Technology for a Hybrid Class with Interface of Blackboard and Connect (McGraw Hill)

April 2018: Invited speaker, for Watson Honors Society (premedical students society at St. John’s University): Title: How to prepare for a career in Medicine.

October 2018: Faculty Technology Forum- exhibit
Title: Effective audiovisual learning tools in Anatomy and Physiology (JoveCore Biology, Youtube and Virtual Reality and Virtual dissection systems)

January 2019:  Biology Department Seminar on the protective and destructive roles of immune cells in the CNS (St. John’s University, Queens, NY)                                               

April 2019: Invited speaker, for Watson Pre-health Honors Society, Roger Bacon Scientific Society, Omega Phi Theta: Title: How to best prepare for a healthcare career