Frank X. Vazquez

Assistant Professor

Dr. Vazquez comes to St. John's University as an Assistant Professor in the chemistry department.  He received his Ph.D. in chemistry from the University of Michigan.  His work is focused on using computational methods to understand how small scale molecular interactions lead to the formation of large scale structures.  Before coming to St. John's, Dr. Vazquez worked at the Thomas J. Watson Research Center in Yorktown Heights, NY.  His research focused on understanding the molecular level causes of Huntington's disease.  He has been coauthor on several journal publications in his field, as well as being a presenter at a number of seminars and workshops.  Presently he is a member of the Society for the Advancement of Chicano/Hispanics and Native Americans in Science (SACNAS) and a member of the American Chemical Society.

The Vazquez group is interested in using multiscale molecular modeling to understand how protein oligomerization influences cellular phenomena. We are especially interested in understanding how oligomerization leads to large-scale changes in the cell and how those changes are influenced by molecular-level interactions. We use and develop multiscale modeling methods that are able simulate large-scale protein oligomers while still taking into account the underlying molecular-level processes. This multiscale view gives us an understanding of how small-scale molecular interactions lead to very large changes in the cell.

H. Kang, F. X. Vázquez, L. Zhang, P. Das, L. Toledo-Sherman, B. Luan, M. Levitt, R. Zhou. Emerging β-sheet rich conformations in super-compact Huntingtin exon-1 mutant structures, J. Am. Chem. Soc., 139 (26), pp 8820. 2017

L. Zhang, H. Kang, F. X. Vázquez, L. Toledo-Sherman, B. Luan, R. Zhou. Molecular Mechanism of Stabilizing the Helical Structure of Huntingtin N17 in a Micellar Environment, J. Phys. Chem. B, 121 (18), 4713. 2017

M. K. Karunananda, F. X. Vázquez, E. E. Alp, W. Bi, S. Chattopadhyay, T. Shibata, N. P. Mankad. Experimental determination of metal-metal redox cooperativity and electronic structure in catalytically active Cu-Fe and Zn-Fe heterobimetallic complexes, Dalton Trans. 43 (36), 13361, 201

F. X. Vázquez, S. Talapatra, R. J. Sension,E. Geva (invited paper). The origin of solvent effects on the cis-trans isomerization rate of hexatriene in liquid solution, J. Phys. Chem. B Special Issue: Jim Skinner Festschrift, 118 (28), 7869, 2014

F. X. Vázquez, V. M. Unger, G. A. Voth. Auto-inhibition of endophilin in solution via inter-domain interactions, Biophys. J., 104 (2), 396, 2013

H. Cui, C. Mim, F. X. Vázquez, E. Lyman, V. M. Unger, G. A. Voth. Understanding the role of amphipathic helices in N-BAR domain driven membrane remodeling, Biophys J., 104 (2), 404, 2013

Y. Chen, J. Aardema, S. Kale, Z. Whichard, A. Awomolo, E. Blanchard, B. Chang, D. Rawlings, H. Christensen, W. Khar, T. Strom, D. R. Myers, R. Tran, D. Reece, A. Ju, C. Zhu, F. X. Vázquez, G. A. Voth, W. A. Lam, S. J. Corey, Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling and proplatelet formation, Blood, 122 (10), 1695, 2013

F. X. Vázquez, S. Talapatra, E. Geva, Vibrational energy relaxation in liquid HCl and DCl via the linearized semiclassical method: Electrostriction vs. Quantum Delocalization, J. Phys. Chem. A, 35, 9775, 2011

F. X. Vázquez, I. Navarotskaya, E. Geva, Vibrational energy relaxation rates via the linearized semiclassical method without force derivatives, J. Phys. Chem. A, 14, 5682, 2010.