Both undergraduate and graduate students learn various aspects of scientific research, including designing and executing experiments, utilizing various scientific equipment for research (Biotage® flash chromatography, HPLC, LC-MS, GC-MS, NMR, spectrophotometry) and laboratory management skills. Overall, students gain expertise in the following scientific areas: drug design, chemical synthesis, molecular modeling, natural products chemistry, microbiology, antibacterial drug discovery and anticancer drug discovery. We collaborate with several faculty members within the Department of Pharmaceutical Sciences in the areas of cancer biology, multi-drug resistance to cancer drugs, inflammation associated diseases and tissue-regeneration to successfully develop promising new drug leads.
Narayanan, S.; Wu, Z.-X.; Wang, J.-Q; Ma, H.; Acharekar, N.; Koya, J.; Yoganathan, S.; Fang, S.; Chen, Z.-S.; Pan, Y. The spleen tyrosine kinase inhibitor, entospletinib (GS-9973) restores chemosensitivity in lung cancer cells by modulating ABCG2-mediated multidrug resistance. Int. J. Biol. Sci. 2021, 17, 2652.
Yoganathan, S.*; Alagaratnam, A.; Acharekar, N.; Kong, J. Ellagic Acid and Schisandrins: Natural Biaryl Polyphenols with Therapeutic Potential to Overcome Multidrug Resistance in Cancer. Cells, 2021, 10, 458.
Kong, J.; Wu, X. -Z.; Wei, L.; Chen, Z. -S.*; Yoganathan, S.* Exploration of antibiotic activity of aminoglycosides, ribostamycin alone and in combination with EDTA against pathogenic bacteria. Front. Microbiol., 2020, 11, 1718.
Barasa, L.; Yong, A.; Yoganathan, S.* An efficient chemo-selective N-alkylation methodology for the structure diversification of indolylbenzimidazoles. ChemistrySelect 2020, 5, 3173-3178.
Barasa, L.; Vemana, H.; Surubhotla, N.; Ha, S. S.; Kong, J.; Yong, A.; Croft, J. L.; Dukhande, V.*; Yoganathan, S.* Synthesis and biological evaluation of structurally diverse benzimidazole scaffolds as potential anticancer agents. Anti-Cancer Agents Med. Chem. 2020, 20, 301-314.
Shao, X.; AbdelKhalek, A.; Abutaleb, N. S.; Velagapudi, U. K.; Yoganathan, S.; Seleem, M. N.; Talele, T. T. Chemical space exploration around thieno[3,2-d]pyrimidin-4(3H)-one scaffold led to a novel class of highly active Clostridium difficile inhibitors. J. Med. Chem. 2019, 62, 9772-9791.
Barasa, L.; Yoganathan, S.* An efficient one-pot conversion of carboxylic acids into benzimidazoles via an HBTU-promoted methodology. RSC Adv. 2018, 8, 35824-35830.
Yoganathan, S.; Miller, S. J.* Structure diversification of vancomycin through peptide-catalyzed, site-selective lipidation: A catalysis-based approach to combat glycopeptide-resistant pathogens. J. Med. Chem. 2015, 58, 2367–2377.
For questions or general information about the laboratory, please e-mail Dr. Yoganathan at [email protected].