Guest Speaker: Maureen J. Charron, Ph.D.
Professor of Biochemistry, Medicine (Endocrinology), and Obstetrics
& Gynecology and Women’s Health Albert Einstein College of
Medicine Bronx, New York
Sponsored by: the Department of
Perturbations in the intrauterine and/or perinatal environment
are associated with low birth weight or small for gestational age,
which in turn predisposes offspring to an increased incidence of
cardiovascular disease, diabetes or Metabolic Syndrome in adult
life. Altered intrauterine milieu models, including our gestational
age model of a maternal high fat pro-inflammatory environment,
display pathologic alterations in gene expression in their
offspring. Although the mechanisms underlying the fetal origin of
metabolic disease are poorly understood, there is strong evidence
to suggest that alterations in the epigenome play a critical role
in this process. Exposure to a maternal high fat milieu during
critical periods of development is associated with altered birth
weight, accelerated catch-up growth and increased incidence of
metabolic disease in later life. The potential molecular mechanism
underlying this programming and an overlap in molecular outcome
measures with human subjects will be discussed.
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Date: Tuesday, February 7th, 2012
Time: 4:45 PM - 6:00 PM
Location: DAC Room 206, Queens