2011 Doctoral Seminar Series - College of
Pharmacy & Allied Health Professions
HIV-1 attachment and entry to target host cells are the primary
events in viral infection process, which is initiated by viral
envelope glycoprotein gp120 by binding to the cellular receptor
CD4. This binding has been extensively studied and x-ray structure
of gp120-CD4 complexed with 17b antibody revealed detail binding
site of gp120. A hydrophobic cavity has been identified on gp120
where the residue Phe43 of CD4 penetrates deep inside. We
identified inhibitors in 2005 that target this site and the x-ray
structures confirmed that they bind to the Phe43 cavity. We have
initiated study to optimize the initial lead compounds. The talk
will summarize our study.
Asim K. Debnath, Ph.D.
Head, Laboratory of Molecular Modeling & Drug Design
Lindsley F. Kimball Research Institute of
The New York Blood Center
Hosted by Lin L. Mantell, M.D., Ph.D.
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Date: Monday, October 24, 2011
Time: 5:00 pm to 6:05 pm
Location: D’Angelo Center, Room 206, Queens Campus