Synthesis and Conformational Analysis of the Calcium-releasing Second Messenger cADPR
cyclic Adenosine Diphosphate Ribose (cADPR) is a molecule formed in vivo that causes cells to release calcium ions, thereby activating a number of critical cellular processes. We synthesize cADPR analogs and determine their structures using Nuclear Magnetic Resonance (NMR) spectroscopy in order to determine how their structure relates to their ability to release calcium ions.
This position is open to both undergraduate and graduate students. Undergraduates must have completed a year of organic chemistry. A one-year commitment is expected. Knowledge of biochemistry and/or experience with laboratory instrumentation is helpful.
Chemical synthesis of cADPR analogs. Analysis using HPLC. NMR spectroscopy.
Position Status: Open
Year in Program: Junior or Senior
Semesters Recruiting: Fall, Spring, Summer
Year: Junior, Senior
Position Title: Research Assistant
Hours per Week: 20
Type of Position: Unpaid