Representative Publications

Duttaroy, A. and Yoburn, B.C. In vivo regulation of u-opioid receptor density and gene expression in CXBK and outbred swiss webster mice. Synapse, 2000, 37:118-124. PubMed

Lee, S.C. and Yoburn, B.C. The effect of nimodipine on opioid antagonist-induced upregulation and supersensitivity. Pharmacology, Biochemistry and Behavior, 2000, 66: 347-351. PubMed

Shen, J., Gomes, A.B., Gallagher, A., Stafford, K and Yoburn, B.C. The role of cAMP-dependent protein kinase (PKA) in opioid agonist-induced u-opioid receptor downregulation and tolerance in mice, Synapse, 2000, 38: 322-327. PubMed

Stafford, K., Gomes, A.B., Shen, J and Yoburn, B.C. µ-opioid receptor downregulation contributes to opioid tolerance in vivo, Pharmacology, Biochemistry and Behavior, 2001, 69: 233-237. PubMed

Gomes, B.A., Shen, J., Stafford, K., Patel, M. and Yoburn B.C. µ-Opioid receptor down-regulation and tolerance are not equally dependent upon G-protein signaling, Pharmacology, Biochemistry and Behavior, 2002, 72:273- 278. PubMed

Patel, M., Gomes, B., Patel, C and Yoburn, B.C. Antagonist-induced µ-opioid receptor upregulation decreases G-protein receptor kinase-2 and dynamin-2 abundance in mouse spinal cord. European Journal of Pharmacology, 2002, 446:37-42. PubMed

Patel, M.B., Patel, C.N., Rajashekara, V. and Yoburn, B.C. Opioid agonists differentially regulate µ-opioid receptors and trafficking proteins in vivo. Molecular Pharmacology, 2002, 62: 1464-1470. PubMed

Yoburn, B.C., Gomes, B.A., Rajashekara, V., Patel, C. and Patel, M. Role of Gialpha2-protein in opioid tolerance and mu-opioid receptor downregulation in vivo. Synapse. 2003, 47:109-16. PubMed

Patel, C.N., Rajashekara, V., Patel, K, Purohit, V. and Yoburn, B.C.Chronic opioid antagonist treatment selectively regulates trafficking and signaling proteins in mouse spinal cord. Synapse. 2003, 50:67–76. PubMed

Rajashekara, V., Patel, C. N., Patel, K., Purohit, V. and Yoburn, B. C. Chronic Opioid Antagonist Treatment Dose-Dependently Regulates µ-Opioid Receptors and Trafficking Proteins In Vivo. Pharmacology, Biochemistry and Behavior, 2003, 75: 909-913. PubMed

Yoburn, B.C., Purohit, V., Patel, K. and Zhang, Q. Opioid agonist and antagonist treatment differentially regulates immunoreactive µ-opioid receptors and dynamin-2 in vivo. European Journal of Pharmacology, 2004, 498:87-96. PubMed  see erratum 

Zhang, Q. Purohit, V. and Yoburn, B.C. Continuous opioid agonist treatment dose-dependently regulates µ-opioid receptors and dynamin-2 in mouse spinal cord, Synapse, 2005, 56:123-128. PubMed

Pawar, M., Kumar, P., Sunkaraneni, S, Sirohi, S, Walker, E.A. and Yoburn, B.C. Opioid agonist efficacy predicts the magnitude of tolerance and the regulation of μ-opioid receptors and dynamin-2, European Journal of Pharmacology, 2007, 563:92-101. PubMed

Sirohi, S.,  Kumar, P., and Yoburn, B.C m-Opioid receptor upregulation and functional supersensitivity are independent of antagonist efficacy.  Journal of Pharmacology and Experimental Therapeutics, 2007, 323:701–707. PubMed