Recent Publications

Ashby, Jr. C.R., Paul, M., Gardner E.L., Heidbreider, C.A., Hagan, J.J., Middlemiss, D.N.  The acute administration of the selective D3 receptor antagonist SB-277011A blocks the expression of the conditioned place preference response to heroin in male rats. Synapse, 48(2003) 154-156.

Macdonald, GJ, Branch, CL, Hadley, MS, Johnson, CN, Nash, DJ, Smith, AB, Stemp, G, Thewlis, KM, Vong, AKK, Austin, NE Phillip, J, Winborn, KY, Boyfield, I, Hagan, JJ, Middlemiss, DN, Reavill, C, Riley, GJ, Watson, JM, Parker, SG, Ashby Jr., CR and Wood, M. Design and Synthesis of trans-3-(2-(1-(4-(3-(3-(5-Methyl)-1,2,4-oxadiazolyl)) phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SB-414796) : A Potent and Selective Dopamine D3 Receptor Antagonist.  J. Med Chem (2003) 46:4952-4964.

Patel, J.G., Bartoszyk, G., Edwards, E., Ashby, Jr., C.R. The highly selective 5-hydroxytryptamine (5-HT)2A receptor antagonist, EMD 281014, significantly increases swimming and decreases immobility in male congenital learned helpless rats in the forced swim test.  Synapse (2004) 52:76-78. 

Zheng X, Gilbert J, Campos A, Kline N, Ashby Jr CR, Hagan JJ, Heidbreder CA, Gardner EL.  Blockade of the dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats.  Psychopharmacology (2004) 176:47-56.

Heidbreider, C.A., Andreoli, M., Marcon, C., Thanos, P.K., Ashby Jr., C.R., and Gardner, E.L.  Role of dopamine D3 receptors in the addictive properties of ethanol.  Drugs Today (2004) 40:255-265.

Heidbreder, C.A., Gardner, E.L., Xi, Z.X., Hagan, J.J., Thanos, P.K., Ashby, Jr., C.R. The role of central dopamine D3 receptors in addiction: a review of pharmacological evidence.  Brain Research Reviews (available online Feb, 5, 2005, e-print ahead of publication).