Email: trombetl@stjohns.edu
Work in my laboratory is concerned with the effects of the
dithiocarbamates and metals on the induction of stress proteins and
alterations in cellular antioxidant defense mechanisms. Due to
their range of action the dithiocarbamates have widespread
application in industry, medicine, and agriculture. These compounds
have been reported to produce neuropathological changes in the
areas of the hippocampus and Purkinje cells of the cerebellum. They
have been shown to cause CNS depressant effects characterized by
ataxia, sedation, depression of locomotor activity and disruption
lof active and passive avoidance. By the use of electron
microscopy, molecular biology and biochemical techniques my lab
studies the effects of metal/thiocarbamate complexes on the
neuronal and astrocytic cytoskeleton. In addition, we examine this
disruption in relation cellular protective mechanisms.
Recent publications
Wilson, A. and L.D. Trombetta. The protective effects of zinc on
diethyldithiocarbamate cytotoxicity on rat astrocytes in vitro. Tox
Let. 105:129-140. 1999.
McManus M.F. and L.D. Trombetta. The effects of
diethydithiocarbamate (DDC) on the astrocytic cytoskeleton.
Scanning Microscopy, 9:257-270. 1995.
Delmaestro E. and L.D. Trombetta. The effects fo disulfiram on
the hippocampus and cerebellum of the rat brain: astucy on
oxidative stress. Tox. Let. 76:235-243. 1995.