More Information

Xingguo Cheng

Assistant Professor
Pharmaceutical Sciences
PhD, Toxicology, University of Kansas Medical Center
MS, Zoology/Molecular Biology, Wuhan University
BS, Biology, Wuhan University
Dr. Cheng is currently an Assistant Professor at Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University. Dr. Cheng received Master degree of Zoology from Wuhan University (Wuhan City, Hubei Province, P.R. China) and Ph. D. degree in Toxicology from KU Medical Center (Kansas City, KS, USA). After graduation, Dr. Cheng continued to work at KU Medical Center in the laboratory of Dr. Curtis D. Klaassen as a Postdoctoral fellow and later a Research faculty. In 2012, Dr. Cheng joined St. John’s University as Assistant Professor. The primary goal of the ongoing research in Dr. Cheng’s laboratory is to characterize how to improve the liver function and how to prevent or protect drug-induced liver injury. Dr. Cheng has published over 30 peer-reviewed research articles in the journals such as Drug Metabolism and Disposition, Molecular Pharmacology, Biochemical Pharmacology, Journal of Pharmacology and Experimental Therapeutics, Toxicology, Toxicological Sciences, Toxicology and Applied Pharmacology, and Journal of Biological Chemistry. Dr. Cheng received internal University grants, industry grant, and private research funds to support the research in his laboratory.

Teaching Interests

Toxicology; Biochemistry; Molecular biology

Research Interests

Liver toxicology and pharmacology; Regulation of drug transporters, such as Oatps, Mrps, Ntcp and Bsep; Toxicology of Fgf21; Toxicology of environmental chemicals

Courses Taught

TOX
103
TOXICOLOGY II
TOX
201
METHODS TOXICOLOGIC EVALUATION
TOX
215
ANALYTICAL METHODS TOXICOLOGY
TOX
223
LIVER & KIDNEY TOXICOLOGY
TOX
230
TOXICOLOGY JOURNAL CLUB
TOX
4413
ANALYTICAL & QUANTITATIVE TOX

Select Publications

Journal Articles

Zhang, Y., Zhang, Y., Klaassen, C. D., and Cheng, X. (2017). Alteration of bile acid and cholesterol biosynthesis and transport by perfluorononanoic acid (PFNA) in mice.. Toxicological sciences : an official journal of the Society of Toxicology.

Bu, P., Le , Y., Zhang, Y., Zhang, Y., and Cheng, X. (2017). Berberine-induced Inactivation of Signal Transducer and Activator of Transcription 5 Signaling Promotes Male-specific Expression of a Bile Acid Uptake Transporter.. The Journal of biological chemistry. vol. 292, pp. 4602-4613.

Vispute, S. G., Bu, P., Le , Y., and Cheng, X. (2017). Activation of GR but not PXR by dexamethasone attenuated acetaminophen hepatotoxicities via Fgf21 induction.. Toxicology. vol. 378, pp. 95-106.

Bu, P., Ji, Y., Narayanan, S., Dalrymple, D., Cheng, X., and Serajuddin, A. T. (2017). Assessment of cell viability and permeation enhancement in presence of lipid-based self-emulsifying drug delivery systems using Caco-2 cell model: Polysorbate 80 as the surfactant.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol. 99, pp. 350-360.

Le , Y., Chen, L., Zhang, Y., Bu, P., Dai, G., and Cheng, X. (2017). Epalrestat Stimulated Oxidative Stress, Inflammation and Fibrogenesis in Mouse Liver.. Toxicological sciences : an official journal of the Society of Toxicology.

Rockwell, C. E., Turley, A. E., Cheng, X., Fields, P. E., and Klaassen, C. D. (2017). Persistent alterations in immune cell populations and function from a single dose of perfluorononanoic acid (PFNA) in C57Bl/6 mice.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol. 100, pp. 24-33.

Bu, P., Narayanan, S., Dalrymple, D., Cheng, X., and Serajuddin, A. T. (2016). Cytotoxicity assessment of lipid-based self-emulsifying drug delivery system with Caco-2 cell model: Cremophor EL as the surfactant.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol. 91, pp. 162-71.

Bu, P., Le , Y., Zhang, Y., and Cheng, X. (2016). Hormonal and Chemical Regulation of the Glut9 Transporter in Mice.. The Journal of pharmacology and experimental therapeutics. vol. 360, pp. 206-214.

Cheng, X., Gu, J., and Klaassen, C. D. (2014). Adaptive hepatic and intestinal alterations in mice after deletion of NADPH-cytochrome P450 Oxidoreductase (Cpr) in hepatocytes.. Drug metabolism and disposition: the biological fate of chemicals. vol. 42, pp. 1826-33.

Hou, W. Y., Xu, S. F., Zhu, Q. N., Lu, Y., Cheng, X., and Liu, J. (2014). Age- and sex-related differences of organic anion-transporting polypeptide gene expression in livers of rats.. Toxicology and applied pharmacology. vol. 280, pp. 370-7.

Cheng, X., Zhang, Y., and Klaassen, C. D. (2014). Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in increased bile acids in serum.. The Journal of pharmacology and experimental therapeutics. vol. 351, pp. 105-13.

Cheng, X., Vispute, S. G., Liu, J., Cheng, C., Kharitonenkov, A., and Klaassen, C. D. (2014). Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR).. Toxicology and applied pharmacology. vol. 278, pp. 65-71.

Cheng, X., and Klaassen, C. D. (2009). Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys.. Drug metabolism and disposition: the biological fate of chemicals. vol. 37, pp. 2178-85.

Cheng, X., and Klaassen, C. D. (2008). Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors.. Toxicological sciences : an official journal of the Society of Toxicology. vol. 106, pp. 29-36.

Cheng, X., and Klaassen, C. D. (2008). Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.. Toxicological sciences : an official journal of the Society of Toxicology. vol. 106, pp. 37-45.

Cheng, X., Buckley, D., and Klaassen, C. D. (2007). Regulation of hepatic bile acid transporters Ntcp and Bsep expression.. Biochemical pharmacology. vol. 74, pp. 1665-76.

Chen, C., Cheng, X., Dieter, M. Z., Tanaka, Y., and Klaassen, C. D. (2007). Activation of cAMP-dependent signaling pathway induces mouse organic anion transporting polypeptide 2 expression.. Molecular pharmacology. vol. 71, pp. 1159-64.

Cheng, X., Maher, J., Lu, H., and Klaassen, C. D. (2006). Endocrine regulation of gender-divergent mouse organic anion-transporting polypeptide (Oatp) expression.. Molecular pharmacology. vol. 70, pp. 1291-7.

Keywords: 
Liver toxicology and pharmacology
Drug transporters, Fibroblast growth factors