More Information

Woon-Kai Low

Associate Professor
Pharmaceutical Sciences
Array

Research Interests

Investigate the process of protein translation initiation in eukaryotic cells in cancer cell lines. Explore therapeutic intervention for cancer that targets the translation initiation process using small molecules and derivatives of natural products.

Courses Taught

BIT
270
INTRO TO BIOTECHNOLOGY
PHS
270
INTRO TO BIOTECHNOLOGY
PHS
2201
BIOPHARMACEUTICAL CHEMISTRY
PHS
3101
INTRODUCTION TO PATHOLOGY
TOX
1401
MOLECULAR TOXICOGENOMICS
TOX
1402L
TOXICOGENOMICS LABORATORY

Select Publications

Journal Articles

Low, W. (2014). “Investigation of the conserved glutamate immediately following the DEAD box in eukaryotic translation initiation factor 4AI”. Biochem. Cell. Biol..

Low, W. (2014). “Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents”. Bioorg. Med. Chem..

Low, W. (2014). Oral Delivery of Glucagon Like Peptide-1 by a Recombinant Lactococcus lactis. Pharm Res.

Low, W. (2014). Re-evaluation of desmethy, desamino-Pateamine A targeting of eukaryotic translation initiation factor 4F. Experimental Biology.

Low, W. (2013). “In vitro structure/activity relationship studies of second generation derivatives of the translation initiation inhibitor desmethyl, desamino-Pateamine A. Experimental Biology.

Low, W. (2012). “Synthesis and SAR optimization of quinazolin-4(3H)-ones as poly(ADP-ribose) polymerase-1 inhibitors”. Eur. J. Med. Chem.

Low, W. (2011). A Calcineurin-independent mechanism of angiogenesis inhibition by a nonimmunosuppressive cyclosporine A analog. J. Pharmacol. Exp. Ther. .

Low, W. (2011). Investigation of the interaction between eukaryotic translation initiation factors eIF4G and eIF4A through mutational analysis. Experimental Biology.

Low, W. (2011). XPB, a subunit of TFIIH, is a target of the antiproliferative and immunosuppressive natural product triptolide. Nat. Chem. Biol.

Low, W. (2009). Inhibition of nonsense-mediated mRNA decay by the natural product pateamine A through initiation factor 4AIII. J. Biol. Chem.

Low, W. (2007). Substrate-dependent targeting of eukaryotic translation initiation factor 4A by pateamine A: negation of domain-linker regulation of activity. Chem. Biol..

Low, W. (2006). Eukaryotic Initiation Factor 2.-independent Pathway of Stress Granule Induction by the Natural Product Pateamine A. J. Biol. Chem.

Low, W. (2006). Synthesis, Characterization, and Utility of Thermoresponsive Natural/Unnatural Product Macroligands for Affinity Chromatography. Org. Lett..

Low, W. (2005). “Inhibition of Eukaryotic Translation Initiation by the Marine Natural Product Pateamine A. Mol. Cell.

Others

Low, W. (2011). Mutational analysis of conserved residues in the eukaryotic translation initiation factor eIF4AI. Experimental Biology.

Low, W. (2010). The immunosuppressant drug cyclosporine A inhibits angiogenesis via a calcineurin-independent mechanism. Angiogenesis in Health and Disease.