I am currently interested in the synthesis, reactions, and medicinal applications of alpha lactams. Alpha Lactams, also known as aziridinones, are three-membered rings containing the amide functional group. Due to their highly strained ring, alpha lactams can lead to interesting chemical reactions and can potentially possess desirable medicinal effects, such as anticancer or antibiotic properties. If you are interested in the synthesis and characterization of organic compounds, their stereochemistry, or their medicinal properties, then a research project in my lab might interest you.
Hoffman, R.V. and Cesare, V. Science of Synthesis, Houben-Weyl Methods of Molecular Transformations, Vol. 21, Chapter 8, Shinkai, I. and Weinreb, S., Eds., Georg Thieme Verlag: Stuttgart, 2005.
Cesare, V., Sadarangani, I., Rollins, J., and Costello, D., The Synthesis and Isolation of N-tert-Butyl-2-phenylsuccinamic Acid and N-tert-Butyl-3-phenylsuccinamic Acid. An Undergraduate Organic Chemistry Laboratory Experiment. J. Chem. Educ., 2004, 81(5), 713-714.
Lengyel, I., Cesare, V., and Taldone, T., A Direct Link Between the Passerini Reaction and -Lactams. Tetrahedron, 2004, 60/5, 1107-1124.
Cesare, V., Taldone, T., and Lengyel, I. About the Factors Which Govern the Ring-opening of -Lactams with Primary Amines: II. The Relative Basicity of the Amine. Heterocycles, 2002, 57, 1851-1868.
Cesare, V., Lyons, T.M., and Lengyel, I. A High-Yielding General Synthesis of -Lactams, Synthesis, 2002, 1716-1720.
Lengyel, I., Cesare, V., Chen, S., and Taldone, T., About the Factors which Govern the Ring-Opening of -Lactams with Benzylamine: The Relative Stability of the -Lactam and the Substituent on Nitrogen. Heterocycles, 2002, 57, 677-695.
Lengyel, I., Cesare, V., Adam, I., and Taldone, T., About Four New Tritylsubstituted -Lactams. Heterocycles, 2002, 57, 73-95.
Stephani, R., Cesare, V., Sadarangani, I., Lengyel, I. Synthesis of New Optically Active and Racemic Phenylsuccinamic Acids, Synthesis, 2002, 47-52.
Cesare, V., Costello, D., Rollins, J. Organic Chemistry Laboratory Manual, Pearson Custom Publishing, Boston, 2001.
Lengyel, I., Cesare, V., Taldone, T., Uliss, D. The Synthesis, Physical and Spectral Properties, and Some Reactions of a New Stable bis--Lactam (Aziridinone) with a Terpene Skeleton, Synth. Commun., 2001, 31(23), 103-115.
Lengyel, I., Cesare, V., Karram, H., Taldone, T. About 1-Triphenylmethyl-3-tert butylaziridinone and Some of Its Reactions, J. Heterocyclic Chem., 2001, 38, 997-1002.
Lengyel, I., Cesare, V., Taldone, T. About the Reaction of 2,3-dibromo-2-methyl N-(1-adamantyl)-propanamide with Sodium tert-Butoxide. A Competition Experiment, Synth. Commun., 2001, 31(16), 2499-2506.
Stephani, R. and Cesare, V. Enantiomeric enrichment of non-racemic antihistamines by achiral high performance liquid chromatography. J. Chromatog. A, 1998, 813, 79-84.
Lengyel, I.; Cesare, V.; Stephani, R. t-Butyl hypochlorite: a powerful electrophilic aromatic ring chlorinating agent. Synth. Commun., 1998, 28(10), 1891-1896.
Stephani, R. and Cesare, V. Resolution of racemic phenylsuccinic acid using (-)-proline as the resolving agent: an introductory laboratory experiment. J. Chem. Educ., 1997, 74, 1226.
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