More Information

Tanaji Talele

Professor
Pharmaceutical Sciences
PhD, Medicinal Chemistry, Institute of Chemical Technology (formerly UDCT)
MS, Medicinal Chemistry, Institute of Chemical Technology (formerly UDCT)
BS, Pharmacy, College of Pharmacy, University of Pune
Tanaji T. Talele obtained his Ph.D. (1998) in Medicinal Chemistry from the University of Mumbai, India. He was a postdoctoral fellow at UMD-New Jersey Medical School, Louisiana State University, and Moffitt Cancer Center (1999-2005). He joined the SJU’s College of Pharmacy and Health Sciences in 2005 where he is currently a Full Professor. He has authored/coauthored 89 peer-reviewed research papers. He has served as a Reviewer for three grant agencies — Campbell Foundation FL, National Health and Medical Research Council (NHMRC) of the Government of Australia and Fondazione Telethon, Italy. Since January 2016 he has been serving as an editorial advisory board member of the European Journal of Medicinal Chemistry. His current research interests include development of small molecule inhibitors of poly(ADP-ribose)polymerase, P-glycoprotein and C. difficile.

Teaching Interests

I find teaching medicinal chemistry courses to Pharm.D., M.S. and Ph.D. students an exciting part of my job.

Research Interests

Development of Poly(ADP-ribose)polymerase (PARP) inhibitors for the treatment of cancer. Development of P-glycoprotein inhibitors as MDR reversal agents. Development of highly active and selective anti-C. difficile agents.

Courses Taught

BIT
348
RECEPTOR & MECH OF DRUG ACTION
MCM
231
MEDICINAL CHEM JOURNAL CLUB
MCM
248
RECEPTORS & MECH DRUG ACTION
MCM
266
PRINCIPLES OF DRUG DESIGN II
PHR
4109
D&D:SKIN CONNECT TISSUE &MISC

Select Publications

Journal Articles

Talele, T. (2017). Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.. Journal of medicinal chemistry.

Wang, Y. J., Patel, B. A., Anreddy, N., Zhang, Y. K., Zhang, G. N., Alqahtani, S., Singh, S., Shukla, S., Kaddoumi, A., Ambudkar, S. V., Talele, T., and Chen, Z. (2017). Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1.. Scientific reports. vol. 7, pp. 42106.

Talele, T. (2016). The "Cyclopropyl Fragment" is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules.. Journal of medicinal chemistry. vol. 59, pp. 8712-8756.

AbdelKhalek, A., Ashby, Jr, C. R., Patel, B. A., Talele, T., and Seleem, M. N. (2016). In Vitro Antibacterial Activity of Rhodanine Derivatives against Pathogenic Clinical Isolates.. PloS one. vol. 11, pp. e0164227.

Werner, M. M., Patel, B. A., Talele, T., Ashby, C. R., Li , Z., and Zauhar, R. J. (2015). Dual inhibition of Staphylococcus aureus DNA gyrase and topoisomerase IV activity by phenylalanine-derived (Z)-5-arylmethylidene rhodanines.. Bioorganic & medicinal chemistry. vol. 23, pp. 6125-37.

Patel, M., Bhatt, A., Steffen, J. D., Chergui, A., Murai, J., Pommier, Y., Pascal, J. M., Trombetta, L. D., Fronczek, F. R., and Talele, T. (2014). Discovery and structure-activity relationship of novel 2,3-dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2H)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 inhibitors.. Journal of medicinal chemistry. vol. 57, pp. 5579-601.

Singh, S., Prasad, N. R., Chufan, E. E., Patel, B. A., Wang, Y. J., Chen, Z., Ambudkar, S. V., and Talele, T. (2014). Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid.. Journal of medicinal chemistry. vol. 57, pp. 4058-72.

Talele, T., Prasad, N. R., Kapoor, K., Chufan, E. E., Patel, B. A., Ambudkar, S. V., and Talele, T. (2014). Design, synthesis, and biological evaluation of (S)-valine thiazole-derived cyclic and noncyclic peptidomimetic oligomers as modulators of human P-glycoprotein (ABCB1).. Chembiochem : a European journal of chemical biology. vol. 15, pp. 157-69.

Patel, B. A., Ashby, Jr, C. R., Hardej, D., and Talele, T. (2013). The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds.. Bioorganic & medicinal chemistry letters. vol. 23, pp. 5523-7.

Patel, B. A., Krishnan, R., Khadtare, N., Gurukumar, K. R., Basu, A., Arora, P., Bhatt, A., Patel, M., Dana, D., Kumar, S., Kaushik-Basu, N., and Talele, T. (2013). Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase.. Bioorganic & medicinal chemistry. vol. 21, pp. 3262-71.

Kulkarni, S. S., Singh, S., Shah, J. R., Low, W., and Talele, T. (2012). Synthesis and SAR optimization of quinazolin-4(3H)-ones as poly(ADP-ribose)polymerase-1 inhibitors.. European journal of medicinal chemistry. vol. 50, pp. 264-73.

Keywords: 
Medicinal chemistry, drug discovery