More Information

Marc E. Gillespie

Professor
Pharmaceutical Sciences
PhD, Oncological Sciences, University of Utah
BA, Zoology, University of Vermont
Dr. Marc E. Gillespie received his doctorate in Oncological Sciences from the University of Utah in 1998 and is now is a Professor in the Department of Pharmaceutical Sciences at St. John’s University College of Pharmacy and Health Sciences. As Chair of the College Assessment Committee he has been working and conducting research in assessment including the development of statistical approaches to assessment data analysis, accreditation, program development, and institutional core curriculum assessment. He leads and develops the College assessment program and regularly attending national accreditation and assessment meetings. As Chair of the Institutional Biosafety Committee he provides institutional oversight of recombinant DNA research. Dr. Gillespie leads a research group focused on bioinformatics and biomarker discovery. Current projects range from the identification of chronic low-level lead exposure and manganese toxicity biomarkers to the mechanics of inflammatory inhibitor release. He teaches Pharmacogenomics, Public Health, Human Anatomy & Physiology and has experience from academia and industry to public health policy. He is currently an Editor/Curator for the Reactome Project, a pathway database of cellular level processes from "simple" events (biochemical reactions), to "complex" biological process (cell cycle). This project is a multinational effort to integrate the overwhelming proliferation of genomic data into a human readable and computationally tractable database. Dr. Gillespie has been learning, conducting, developing tools for and teaching science for more than twenty years and is active at all levels of science curriculum development.

Teaching Interests

Public Health, Anatomy, Genomics, Molecular Biology, Bioinformatics, Toxicology, Science Education, and Pharmacogenomics

Research Interests

Protein Biochemistry, Bioinformatics, Toxicology, Systems Biology, Pharmacogenomics, Biocuration, Proteomics, and Toxicology,

Courses Taught

PHS
2101
PUBLIC HEALTH FOR THE PHARM D
PHS
3103
HUMAN ANATOMY& PHYSIOLOGY I
PHS
3507
HUMAN ANATOMY & PHYSIOLOGY II
PHS
3605
INTRO TO PHARMACOGENOMICS

Select Publications

Journal Articles

Talele, T., Gillespie, M. E., and Korlipara, V. L. (2012). Drugs Covered in This Chapter. Foye’s Principles of Medicinal Chemistry. pp. 210.

Gillespie, M. E., Shamovsky, V., and D’Eustachio, P. (2011). Human and chicken TLR pathways: manual curation and computer-based orthology analysis. Mammalian Genome. vol. 22, pp. 130–138.

Woska Jr, JR, , and Gillespie, M. (2011). Small-Interfering RNA-Mediated Identification and Regulation of the Ternary SNARE Complex Mediating RBL-2H3 Mast Cell Degranulation. Scandinavian journal of immunology. vol. 73, pp. 8–17.

Haw, R., Caudy, M., Croft, D., Garapati, P., Gillespie, M. E., Jassal, B., Jupe, S., Kanapin, A., Mahajan, S., Matthews, L., and others, (2010). Innate Immune Signaling Pathways in Reactome. The Journal of Immunology. vol. 184, pp. 94–13.

Matthews, L., Gopinath, G., Gillespie, M. E., Caudy, M., Croft, D., de Bono, B., Garapati, P., Hemish, J., Hermjakob, H., Jassal, B., and others, (2009). Reactome knowledgebase of human biological pathways and processes. Nucleic acids research. vol. 37, pp. D619–D622.

Gillespie, M., Orlic-Milacic, M., and Lee, K. (2008). Report for Golgi Cisternae Pericentriolar Stack Reorganization. Biol. Cell. vol. 19, pp. 2579–87.

Vastrik, I., D’Eustachio, P., Schmidt, E., Joshi-Tope, G., Gopinath, G., Croft, D., de Bono, B., Gillespie, M. E., Jassal, B., Lewis, S., and others, (2007). Reactome: a knowledge base of biologic pathways and processes. Genome biology. vol. 8, pp. R39.

Gillespie, M. E. (2006). Biomarker discovery and compound evaluation using two-hybrid proteomic systems. Informa UK Ltd London, UK.

Joshi-Tope, G., Gillespie, M. E., Vastrik, I., D’Eustachio, P., Schmidt, E., de Bono, B., Jassal, B., Gopinath, G., Wu, G., Matthews, L., and others, (2005). Reactome: a knowledgebase of biological pathways. Nucleic acids research. vol. 33, pp. D428–D432.

Gillespie, M., Matthews, L., Rice, A., and Gopinathrao, G. (2004). Report for Late Phase of HIV Life Cycle. Biochem Cell Biol. vol. 36, pp. 1767–75.

Gillespie, M. E. (2003). Affordable proteomics: the two-hybrid systems.. Current opinion in molecular therapeutics. vol. 5, pp. 266–270.

Carvalho, F., and Gillespie, M. E. (2003). Bringing proteomics into the lab: Proteomics lab 101. Biochemistry and Molecular Biology Education. vol. 31, pp. 46–51.

Gillespie, M. (2003). Report for Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters. membranes. vol. 278, pp. 8725–32.

Joshi-Tope, G., Vastrik, I., Gopinath, G., Matthews, L., Schmidt, E., Gillespie, M. E., D’EUSTACHIO, P., Jassal, B., Lewis, S., Wu, G., and others, (2003). The Genome Knowledgebase: a resource for biologists and bioinformaticists. Cold Spring Harbor symposia on quantitative biology. vol. 68, pp. 237–244.

Rotondo, G., Gillespie, M. E., and Frendewey, D. (1995). Rescue of the fission yeast snRNA synthesis mutant snm1 by overexpression of the double-strand-specific Pac1 ribonuclease. Molecular and General Genetics MGG. vol. 247, pp. 698–708.

Kornblihtt, A., Proudfoot, N., Marzluff, W., Wahle, E., and Gillespie, M. (1985). Report for Post-Elongation Processing of the Transcript. Cell. vol. 41, pp. 845–55.

Book Chapters

Schmidt, E., Birney, E., Croft, D., de Bono, B., D’Eustachio, P., Gillespie, M. E., Gopinath, G., Jassal, B., Lewis, S., Matthews, L., and others, (2006). Reactome–a knowledgebase of biological pathways. In: On the Move to Meaningful Internet Systems 2006: OTM 2006 Workshops. Springer Berlin Heidelberg. pp. 710–719.

Conference Proceedings

Carvalho, F., Trivedi, M., and Gillespie, M. E. (2004). Molecular toxicity marker identification: A small scale proteomic approach. In: FASEB JOURNAL. vol. 18, pp. C65–C65.

Gillespie, M. E. (2003). A proteomic approach to identify the molecular targets of lead and acrylamide neurotoxicity in the neuronal snare protein circuitry that underlies neurotransmitter release.. In: TOXICOLOGICAL SCIENCES. vol. 72, pp. 13–13.

FRENDEWEY, D., Gillespie, M. E., and TARNOK, J. (1993). THE PAC1+ GENE OF SCHIZOSACCHAROMYCES-POMBE ENCODES A POSSIBLE HOMOLOG OF ESCHERICHIA-COLI RIBONUCLEASE-III. In: JOURNAL OF CELLULAR BIOCHEMISTRY. pp. 177–177.