More Information

Louis D. Trombetta, Ph.D.

Professor
Pharmaceutical Sciences

Research Interests

Environmental and developmental neurotoxicants and their relationship to neurodegeneration; Cell injury and alterations in cellular antioxidant defense mechanisms are studied; Electron microscopy

Courses Taught

PHS
240
PRINCIPLES ELECTRON MICROSCOPY
PHS
240L
ELECTRON MICROSCOPY LABORATORY
PHS
3101
INTRODUCTION TO PATHOLOGY
PHS
4204
INTRO TO CLINICAL CHEMISTRY
TOX
222
CELLULAR PATHOPHYSIOLOGY
TOX
4403
TOXICOLOGY COLLOQUIUM

Select Publications

Journal Articles

Trombetta, L. D. (2016). Exposure of rat hippocampal astrocytes to Ziram increases oxidative stress. Toxicology and Industrial Health.

Trombetta, L. D. (2014). Discovery and SAR of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors. J Med Chem..

Trombetta, L. D. (2013). Use of the mouse ear vesicant model to evaluate the effectiveness of ebselen as a countermeasure to the nitrogen mustard mechlorethamine. J. Appl. Toxicol.

Trombetta, L. D. (2013). Maneb causes pro-oxidant effects in the hippocampus of Nrf2 knockout mice. Environmental Toxicology and Pharmacology.

Trombetta, L. D. (2013). Development of Solid SEDDS, IV: Effect of Adsorbed Lipid and Surfactant on Tableting Properties and Surface Structures of Different Silicates. Pharm Res.

Trombetta, L. D. (2008). Toxicity and bioaccumulation of the wood preservative copper dimethyldithiocarbamate in tissues of long-evans rats. Journal of Toxicology and Environmetal Health.

Trombetta, L. D. (2007). The protective role of chelators and antioxidants on Mancozeb-induced toxicity in rat hippocampal astrocytes. Toxicology and Industrial Health.

Trombetta, L. D. (2007). The effects of the wood preservative copper dimethyldithiocarbamate in the hippocampus of maternal and newborn Long-Evans rats. Toxicology Letters.

Trombetta, L. D. (2006). Delivery of TEM beta-lactamase by gene-transformed Lactococcus lactis subsp. Lactis, through cervical cell monolayer. International Journal of Pharmaceutics.

Trombetta, L. D. (2006). Acute toxicity and bioaccumulation of tributyltim in tissues of Urolophus jamaicensis (yellow stingray). Journal of toxicology and Environmental Health.

Trombetta, L. D. (2004). The Induction of Amyloid Precursor Protein (APP) and .-Synuclein in Rat Hippocampal Astrocytes by Diethyldithiocarbamate (DDC) and Copper with or without Glutathione (GSH). Toxicology Letters.

Trombetta, L. D. (2004). Biodegration Behavior of Gellan Gum in simulated coonic media. Pharmaceu. Develop. Tech.

Trombetta, L. D. (2003). The role of chemically-induced glutathione and glutathione S-transferase in protecting against 4-hydroxy-2nonenal-mediated cytoxicity in vascular smooth muscle muscle Cells. Cardiovascular Toxicology.

Trombetta, L. D. (2003). Induction of Cellular glutathione and glutathione S-transferase by 3H-1,2-dithiole-3-thione iin rat aortic smooth muscle in A19 cells: protection against acrolein-induced toxicity. Athersclerosis.

Trombetta, L. D. (2002). The effects of ebselen on cisplatin and diethyldithiocarbamate (DDC) cytotoxicity in rat hippocampal astrocytes. Toxicology Letters.

Trombetta, L. D. (2000). The relationship between stress protein induction and the oxidative defense system in the rat hippocampus following kainic acid administratrion. Toxicology Letters.

Trombetta, L. D. (1999). The protective effects of zinc on diethyldithiocarbamater cytotoxicity on rat astroxytes in vitro. Toxicology Letters.

Trombetta, L. D. (1995). The effects of disulfiram on the hippocampus and cerebellum of the rat brain: a study on oxidative stress. Toxicology Letters.

Trombetta, L. D. (1995). The effects of diethyldithiocarbamate (DDC) on the astrocytic cytoskeleton. Scanning Microscopy.

Book Chapters

Trombetta, L. D. (1994). Anti-oxidant enzyme activity as biomarkers of acid stress in natural aquatic systems. In: Muller R. and Lloyd R.. The sublethal and chronic effects of pollutants on freshwater fish. Fishing News Books, Blackwell Science.